The in vitro hepatitis C virus infection system as a drug discovery tool

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,713.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI074101-01
Award Id:
85316
Agency Tracking Number:
AI074101
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
APATH, LLC, 893 N. WARSON RD., SAINT LOUIS, MO, 63141
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
075127220
Principal Investigator:
AMINE NOUEIRY
(314) 812-8160
NOUEIRY@APATH.COM
Business Contact:
JANET MILTON
() -
milton@apath.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a major cause of liver disease throughout the world. Existing therapies are suboptimal and the search for alternative therapies is imperative. Recent years have seen a tremendous inc rease in efforts to identify more effective therapies against HCV. These efforts have been greatly facilitated by sub-genomic HCV replicon systems that efficiently replicate in cell culture. However, despite all the benefits of these replicon systems, the lack of an infectious HCV system in cell culture is still an impediment to all aspects of HCV studies, particularly the development of HCV anti-viral therapies. The recent development of an HCV clone that is infectious in cell culture (termed HCVcc) can di rectly address these shortcomings. The focus of this proposal is to develop the HCVcc system as a more useful tool for drug development. This includes identifying culture methods for increasing HCVcc titer, developing HCVcc genotypes relevant to the domina nt drug development target, and facilitating drug cross-resistance studies by generating mutant infectious HCV viruses that harbor drug resistance mutations reported against experimental anti-HCV compounds presently being developed and evaluated. Results o btained here will not only directly benefit drug development efforts, but will also provide critical information and reagents to a rapidly-developing field of basic research. Infectious HCV for drug discovery.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government