Supercritical Fluid Extraction of Michellamine B

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$637,570.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 CA65368-1,
Award Id:
24929
Agency Tracking Number:
24929
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Aphios Corp. (Currently APHIOS CORPORATION)
3-E Gill Street, Woburn, MA, 01801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Trevor Castor
(617) 932-6933
Business Contact:
() -
Research Institution:
n/a
Abstract
Michellamine B is a potential anti-HIV agent isolated from the leaves of a Cameroonian vine,Ancistrocladus korupensis, which grows in the Korup region of Cameroon. Preclinical testing ofMichellamine B by the National Cancer Institute may be adversely impacted by raw materials availability,and the inefficiencies of conventional, large-scale manufacturing processes. The latter is time, labor andmaterial-intensive, utilizes large quantities of organic solvent which can become an environmentalquagmire, and requires extracting and expensive HPLC techniques. Multiple processing steps arerequired resulting in low yields and high costs. Processing time, organic solvent usage andmanufacturing costs may be significantly reduced by the use of supercritical fluid solvents. Our specificaim to determine if Michellamine B can be isolated and purified from Ancistrocladus korupensis tissueby the use of supercritical fluid extraction and chromatographic purification techniques. Thisinvestigation should lead to the development of an improved manufacturing process for cost-effectivelyproducing large quantities of Michellamine B needed for preclinical development and clinical trials.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government