Supercritical Fluid Extraction of Michellamine B

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 CA65368-1,
Agency Tracking Number: 24929
Amount: $637,570.00
Phase: Phase II
Program: SBIR
Awards Year: 1996
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
3-E Gill Street, Woburn, MA, 01801
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Trevor Castor
 (617) 932-6933
Business Contact
Phone: () -
Research Institution
Michellamine B is a potential anti-HIV agent isolated from the leaves of a Cameroonian vine,Ancistrocladus korupensis, which grows in the Korup region of Cameroon. Preclinical testing ofMichellamine B by the National Cancer Institute may be adversely impacted by raw materials availability,and the inefficiencies of conventional, large-scale manufacturing processes. The latter is time, labor andmaterial-intensive, utilizes large quantities of organic solvent which can become an environmentalquagmire, and requires extracting and expensive HPLC techniques. Multiple processing steps arerequired resulting in low yields and high costs. Processing time, organic solvent usage andmanufacturing costs may be significantly reduced by the use of supercritical fluid solvents. Our specificaim to determine if Michellamine B can be isolated and purified from Ancistrocladus korupensis tissueby the use of supercritical fluid extraction and chromatographic purification techniques. Thisinvestigation should lead to the development of an improved manufacturing process for cost-effectivelyproducing large quantities of Michellamine B needed for preclinical development and clinical trials.

* Information listed above is at the time of submission. *

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