REVERSED MICELLAR FRACTIONATION

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$271,353.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
27328
Agency Tracking Number:
27328
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3-e Gill St, Woburn, MA, 01801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Maury Cosman
(617) 932-6933
Business Contact:
() -
Research Institute:
n/a
Abstract
NUMEROUS COMPOUNDS SHOWING ANTINEOPLASTIC ACTIVITY HAVE BEEN IDENTIFIED IN THE ORGANIC SOLVENT EXTRACTS OF PLANT MATERIAL, MICROORGANISMS, AND MARINE ORGANISMS. FURTHER INVESTIGATION INTO THE UTILITY OF THESE COMPOUNDS AS CHEMOTHERAPEUTIC AND ANTI-HIV AGENTS HAS BEEN HAMPERED BY THEIR LOW NATURAL ABUNDANCE AND THE INEFFICIENCIES OF CONVENTIONAL EXTRACTION TECHNIQUES. THESE TECHNIQUES CAN ALSO RESULT IN A FINAL PRODUCT WITH RESIDUAL TOXICITIES AND GENERATE SIGNIFICANT QUANTITIES OF WASTE ORGANICS WHICH ARE A DISPOSAL AND ENVIRONMENTAL BURDEN. THE GOAL OF THE RESEARCH AND DEVELOPMENT PROGRAM IS TO DEVELOP AN IMPROVED PROCESS FOR CRYSTALLIZING/PURIFYING NATURAL PRODUCT MEDICINALS WITH ANTI-CANCER, ANTI-HIV, AND ANTI-MALARIAL ACTIVITIES. INHERENT IN THIS GOAL IS THE DEVELOPMENT OF A PROCESS WHICH CAN RAPIDLY CRYSTALLIZE LARGE QUANTITIES OF NATURAL PRODUCT THERAPEUTICS FOR CLINICAL DEVELOPMENT AND COMMERCIAL USE, IMPROVE THE QUALITY OF THE END-PRODUCT WHILE SIGNIFICANTLY REDUCING MANUFACTURING COSTS, AND CONCURRENTLY MINIMIZE THE IMPACT ON THE ENVIRONMENT AND BIODIVERSITY. THE DEVELOPED PROCESS SHOULD BE GENERICALLY APPLICABLE TO THE MANUFACTURING OF NATURAL PRODUCT MEDICINALS WHICH CONSTITUTE ABOUT 25 PERCENT OF PRESCRIPTION THERAPEUTICS USED IN THE UNITED STATES.

* information listed above is at the time of submission.

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