Short-Wavelength Countermeasure for Circadian Desynchrony

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$99,984.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
FA9550-07-C-0058
Award Id:
83337
Agency Tracking Number:
F074-015-0084
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
947 South 500 East, Suite 210, American Fork, UT, 84003
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
180588139
Principal Investigator:
Dan Adams
Director of Research
(801) 492-1210
dadams@apollohealth.com
Business Contact:
Kent Savage
CEO
(801) 492-1210
ksavage@apollohealth.com
Research Institute:
BRIGHAM & WOMEN'S HOSPITAL
Ninoska Rosado
Division of Sleep Medicine
221 Longwood Avenue
Boston, MA, 2115
(617) 954-9660
Nonprofit college or university
Abstract
Air Force operations often expose flight crew and support staff to unusual light-dark cycles that causes misalignment of the circadian pacemaker and sleep-wake cycles, resulting in disturbed sleep and impaired waking function. Air Force personnel are also frequently required to remain vigilant, often under conditions of acute or chronic sleep deprivation. An effective countermeasure is required to facilitate rapid adaptation of the circadian system and/or to enhance alertness and performance directly. Light induces both of these effects and is a safe, non-pharmacological countermeasure for circadian- and fatigue-related cognitive deficits. Recently, we have shown that short-wavelength (blue) light at night is the most effective wavelength for phase-shifting the circadian pacemaker, suppressing melatonin, enhancing subjective alertness, improving performance and inducing brain activation. Further work is required to confirm that blue light is also the most effective wavelength in the day and at all light intensities. In this proposal, we aim to compare the effectiveness of day-time blue or green narrow-band LED exposure to enhance alertness, performance and EEG activation using a small, portable light source (goLITE, Apollo Light Systems Inc.). Based on these results, we intend to develop a 'smart' portable LED light source to enhance alertness and performance in operational settings.

* information listed above is at the time of submission.

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