Development of APMS as a Chromatographic Substrate

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41GM071059-01A1
Agency Tracking Number: GM071059
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2005
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Apollo Sri, Llc, 173 Staniford Rd, Burlington, VT, 05401
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CHRISTOPHER LANDRY
 (802) 656-0270
 CHRISTOPHER.LANDRY@UVM.EDU
Business Contact
Phone: (832) 567-3593
Research Institution
 UNIVERSITY OF VERMONT
 85 SOUTH PROSPECT STREET
340 WATERMAN BUILDING
BURLINGTON, VT, 05405
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. These benefits are due to the physical properties of APMS, which consists of regular 5 um spheres with a surface area of 1100 m2/g. The proposed research has three main goals: (1) to initiate studies on larger-scale production of APMS; (2) to expand previous studies on chiral separations; and (3) to study the potential uses of APMS in size-exclusion chromatography. The ultimate goal of this research will be to produce a suite of HPLC column materials. The HPLC columns market is $500M and growing at 8% annually. Because HPLC is a standard research tool, successful commercialization of APMS will benefit society and researchers by accelerating the major advances in understanding fundamental life processes. In particular, APMS could facilitate liquid chromatography-mass spectrometry (LC-MS), size exclusion chromatography (SEC), and chiral separations.

* Information listed above is at the time of submission. *

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