Novel Detergents for Membrane Proteins

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 DK48687-01,
Agency Tracking Number: 29372
Amount: $80,184.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Applied Biotech Concepts, Inc.
25 Science Park, New Haven, CT, 06511
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Anil Diwan
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and hopefcrystals than the presently used detergents. Two families of novel detergents will be synthesized, pchemically characterized,. A few selected detergents will then be tested at the Lawrence Berkeley Lab/c1 complex and PhoE Porin for the ability to promote crystallization and the type, size and diffraformed.

* information listed above is at the time of submission.

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