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Novel Detergents for Membrane Proteins
Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 DK48687-01,
Agency Tracking Number: 29372
Amount:
$80,184.00
Phase:
Phase I
Program:
SBIR
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Timeline
Solicitation Year:
N/A
Award Year:
1995
Award Start Date (Proposal Award Date):
N/A
Award End Date (Contract End Date):
N/A
Small Business Information
25 Science Park
New Haven, CT
06511
United States
DUNS:
N/A
HUBZone Owned:
No
Woman Owned:
No
Socially and Economically Disadvantaged:
No
Principal Investigator
Name: Anil Diwan
Phone: () -
Phone: () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and hopefcrystals than the presently used detergents. Two families of novel detergents will be synthesized, pchemically characterized,. A few selected detergents will then be tested at the Lawrence Berkeley Lab/c1 complex and PhoE Porin for the ability to promote crystallization and the type, size and diffraformed.
* Information listed above is at the time of submission. *