Novel Detergents for Membrane Proteins

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$80,184.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 DK48687-01,
Award Id:
29372
Agency Tracking Number:
29372
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
25 Science Park, New Haven, CT, 06511
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Anil Diwan
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and hopefcrystals than the presently used detergents. Two families of novel detergents will be synthesized, pchemically characterized,. A few selected detergents will then be tested at the Lawrence Berkeley Lab/c1 complex and PhoE Porin for the ability to promote crystallization and the type, size and diffraformed.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government