Novel Detergents for Membrane Proteins

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$80,184.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 DK48687-01,
Agency Tracking Number:
29372
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Applied Biotech Concepts, Inc.
25 Science Park, New Haven, CT, 06511
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Anil Diwan
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and hopefcrystals than the presently used detergents. Two families of novel detergents will be synthesized, pchemically characterized,. A few selected detergents will then be tested at the Lawrence Berkeley Lab/c1 complex and PhoE Porin for the ability to promote crystallization and the type, size and diffraformed.

* information listed above is at the time of submission.

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