Natural Adjuvants to enhance Efficacy of Viral Vaccines for Mariculture

Award Information
Agency: Department of Commerce
Branch: N/A
Contract: WC133R10CN0227
Agency Tracking Number: 10-96
Amount: $92,716.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 1
Solicitation Topic Code: 8.1.2
Solicitation Number: NOAA 2010-1
Small Business Information
ProFishent Incorporated
17806 NE 26TH ST, REDMOND, WA, 98052
DUNS: 179038190
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Powell
 Vice President, R & D
 (425) 883-9896
 davidp@profishent.com
Business Contact
 Roger Palm
Title: President
Phone: (425) 883-9896
Email: rogerp@profishent.com
Research Institution
N/A
Abstract

Viral diseases are a major impediment to the development and expansion of environmentally safe and sustainable aquaculture systems (NMFS 2007). Despite control measures, pathogenic viruses kill millions of fish and shellfish every year (ICES Mariculture Committee 2004). To date, vaccines against fish viruses have generally provided extremely poor protection or are too expensive (e.g. DNA vaccines). We will test the feasibility of binding natural marine and terrestrial biological structures to viruses to boost the immunogenicity of viral antigens delivered to the gills and mucosal surfaces of aquatic animals. A nanotechnology-based dynamic light scattering laser instrument will verify the attachment of the model virus particles. Groups of Atlantic Salmon (Salmo salar) will then undergo needle-less, immersion immunization with the most promising vaccine formulations to assess safety and efficacy. Antibody titers will be compared to identify candidate vaccine adjuvant systems for further investigations planned in Phase II research.

* information listed above is at the time of submission.

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