PURIFICATION OF PERIPHERAL BLOOD STEM CELLS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$426,900.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
16719
Agency Tracking Number:
16719
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Applied Immunesciences, Inc. (Currently Applied Immune Sciences, Inc.)
200 Constitu- Tion Drive, Menlo Park, CA, 94025
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Lebkowski, Jane S
Principal Investigator
(415) 326-7302
Business Contact:
1 R43 HL46618-01
() -
Research Institution:
n/a
Abstract
APPLIED IMMUNE SCIENCES, INC. HAS DEVELOPED STERILE POLYSTYRENE DEVICES ONTO WHICH MONOCLONAL ANTIBODIES ARE COVALENTLY ATTACHED. THESE DEVICES ARE ROUTINELY USED TO RAPIDLY SEPARATE CELLS WITH SURFACE ANTIGENS SPECIFIC FOR THE IMMOBILIZED ANTIBODY. MOREOVER, THESE DEVICES HAVE BEEN USED SUCCESSFULLY TO PURIFY HEMATOPOIETIC STEM CELLS FROM HUMAN BONE MARROW. THE SPECIFIC AIM OF THIS RESEARCH IS TO USE THESE DEVICES TO EFFICIENTLY COLLECT PERIPHERAL BLOOD STEM CELLS FROM AUTOLOGOUS TRANSPLANT CANDIDATES, THEREBY CREATING A NONTOXIC GENERIC PROCEDURE TO PREPARE PURGED GRAFTS. MOREOVER, IT IS THE PURPOSE OF THIS RESEARCH TO DETERMINE THE LONG TERM HEMATOPOIETIC POTENTIAL OF SUCH PURIFIED PERIPHERAL BLOOD STEM CELLS. IF THIS RESEARCH IS SUCCESSFUL, THE LONG TERM GOAL IS TO DEVELOP LARGE SURFACE AREA DEVICES WHICH WILL EFFICIENTLY AND RAPIDLY PROCESS THE NUMBERS OF CELLS REQUIRED FOR A FULL SIZE TRANSPLANT. AUTOLOGOUS TRANSPLANT WITH PURIFIED PERIPHERAL BLOOD STEM CELLS WILL OFFER SEVERAL ADVANTAGES TO PATIENTS: 1) COLLECTION OF PERIPHERAL BLOOD COULD TAKE PLACE WITHOUT GENERAL ANESTHESIA, 2) THE TOTAL NUMBER OF STEM CELLS COLLECTED AND THEREBY TRANSPLANTED WILL BE GREATER, 3) IN MANY DISEASES, THE PERIPHERAL BLOOD IS LESS CONTAMINATED WITH TUMOR CELLS, 4) THE PURIFIED CD34+ STEM CELLS WILL SERVE AS A PURGED SOURCE OF ENGRAFTABLE MATERIAL, AND 5) ANIMAL EXPERIMENTS INDICATE THAT MORE RAPID ENGRAFTMENT MAY TAKE PLACE WITH PURIFIED STEM CELLS. BECAUSE OF THESE ADVANTAGES, COMMERCIALIZATION OF THESE DEVICES SHOULD BE POSSIBLE.

* information listed above is at the time of submission.

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