Purification and Culture of Dendritic Langerhans Cells

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 21921
Amount: $35,438.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Applied Immune Sciences, Inc.
5301 Patrick Henry Drive, Santa Clara, CA, 95054
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David A. Okrongly
 (408) 492-9200
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Methods for obtaining highly purified Langerhans Cells (LC) directly from epidermis or by directed differentiation of CD34+ progenitor cells are proposed. Development and commercialization of products for LC purification will aid basic research on the role of LC in skin diseases such as psoriasis, Kaposi's sarcoma and atopic dermatitis. The therapeutic goal of the work is to develop a method of growing LC from bone marrow and use the LC as an antigen presenting cell line for cytotoxic CD8+ T cells. We propose applying this system in an immunotherapeutic approach to AIDS; this system will be based on the use of HIV-associated antigens in the LC culture system. The system may provide a generally applicable method for generation of antigen specific cytotoxic T cells.

* information listed above is at the time of submission.

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