Non-Invasive Ultrasonic Intracranial Pressure Measurement

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-10-C-0060
Agency Tracking Number: 09SB2-0066
Amount: $98,148.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2009
Solicitation Topic Code: SB092-003
Solicitation Number: 2009.2
Small Business Information
9500 Innovation Drive, Manassas, VA, 20110
DUNS: 945837219
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John Sevick
 Principal Investigator
 (703) 368-6107
 john.sevick@progeny.net
Business Contact
 Christine Sigety
Title: Manager of Business Support
Phone: (703) 368-6107
Email: csigety@progeny.net
Research Institution
N/A
Abstract
Traumatic Brain Injury (TBI) is the leading cause of death and disability for ages 1 to 44. TBI results in 50,000 deaths, 90,000 survivors suffering permanent neurological disabilities, and $40B in health care costs annually. Insurgents’ use of suicide bombers and IEDs has sharply increased the proportion of TBIs suffered by American troops, making it the “signature wound” in recent conflicts. TBI is difficult to diagnose, treat, and monitor in the field, with no external indication of the internal brain injuries. Rapid detection and treatment of TBI is critical in preventing further damage or death. Computerized axial tomography (CT) is the “gold standard” non-invasive method to determine the degree of cerebral injury, but is not suitable for field. Elevated Intracranial Pressure (ICP), above 20mm HG, is often the most direct, initial result of TBI. However, traditional invasive ICP measurements are also not possible in the field. In conjunction with Virginia Commonwealth University Medical System, Progeny proposes to investigate three non-invasive methods to measure ICP: Ultrasonic image of the optical nerve sheath diameter, Intra-ocular pressure, and a novel ultrasonic sound attenuation technique. Phase I will include prototype data collection system development for deployment in Phase II ICU and ED patient studies.

* Information listed above is at the time of submission. *

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