STRUCTURE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4708
Agency Tracking Number:
4708
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
6554 Beechwood Drive, Independence, OH, 44131
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DENNIS SIEDLAK
PRINCIPAL INVESTIGATOR
(216) 589-5891
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP AN IMPLANTABLE ENZYMATIC-ELECTRO-CHEMICAL SENSOR UTILIZING GLUCOSE OXIDASE HOUSED IN A MICRO-TEXTURED CELL WITH ION TEXTURED SURFACES. THESE ION SURFACES ALLOW ALTERATIONS IN THE FIBROUS CAPSULE FORMATION; THE ALTERATIONS PERMIT INTIMATE CONTACT WITH THE TISSUE VASCULATURE TO THE EXCLUSION OF THE FIBROUS CAPSULE. THE SENSING ELEMENT IS CONSTRUCTED WITH AN EXCLUSION MEMBRANE SYSTEM, BIBULOUS FILMWITH ENZYME SOLUTION AND PLATINUM CATALYTIC SURFACE, THUS COMBINING UNIQUE SURFACE MICROSTRUCTURING WITH A RECHARGEABLE ENZYME SYSTEM. DURING PHASE I A PROTOTYPE MODULE WILL BE TESTED FOR FEASIBILITY OF FABRICATING A SENSOR MODULE WITH HOLLOW, METAL-COATED MICROPILLAR STRUCTURES. PHASE II WILL ALLOW FOR CHARACTERIZATION AND REFINEMENT OF THE ENZYME SYSTEM WITH SMALL ANIMAL STUDIES. ISSUES SUCH AS ENZYME STABILITY, MEMBRANE EXCLUSION PROPERTIES, BONDING, BIOCOMPATIBILITY, RESPONSE TIME, AND LINEARITY WILL BE CHARACTERIZED IN IN VITRO AND IN VIVO MODELS. THIS SENSOR WILL PROVIDE MORE THAN 2 MILLION INSULIN DEPENDENT DIABETICS WITH THE FINE DYNAMIC CONTROL REQUIRED WHEN USING AN ARTIFICIAL BETA CELL. IN ADDITION, BASIC TISSUE INTERACTION WITH ITS IMPLANTATION AND CONTROL OF THE SOFT TISSUE BIOLOGIC INTERFACE CAN BE DIRECTLY APPLIED TO A BROAD RANGE OF IMPLANTS AND THEIR DESIGN.

* information listed above is at the time of submission.

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