SBIR Phase I: Molecular Design of Advanced Monolayers For Improved Surface Amination

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0638251
Agency Tracking Number: 0638251
Amount: $99,968.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2006
Solicitation Topic Code: AM
Solicitation Number: NSF 06-553
Small Business Information
Applied MicroStructures, Inc.
1020 Rincon Circle, Ste. 205, San Jose, CA, 95131
DUNS: 121410679
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jeffrey Chinn
 (408) 718-6254
Business Contact
 Jeffrey Chinn
Title: PhD
Phone: (408) 718-6254
Research Institution
This Small Business Innovation Research (SBIR) Phase I project seeks to fill a need in the arena of advanced monomolecular layers for specific surface functionalities. The project addresses a key limiting factor which prevents many novel biosensors, labchips and BioMEMS from reaching the market, i.e. the chemistry used for coupling biomolecules to interfaces. Aminopropyltrimethoxysilane (APTMS) is the most commonly used linking chemistry today, and it is being used in a wide variety of applications from stationary phases in chromatographic columns, to DNA labchips, to chemical sensors. The control and manipulation of this molecule (and molecular layer(s) it forms), however, remains insufficient and limited. The current proposal aims to arrive at new synthetic routes for amine-terminated molecular layers derived from novel precursors. This could, in turn, lead to the development of next-generation advanced sensors, bioassay devices, DNA chips and other medical diagnostic/therapeutic technologies.

* information listed above is at the time of submission.

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