ACTIVE ENERGY SELECTIVE CASSETTE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
16432
Agency Tracking Number:
16432
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2369 Laura Lane, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Alvarez, Robert E
Principal Investigator
(415) 968-9794
Business Contact:
1 R43 CA55430-01
() -
Research Institution:
n/a
Abstract
DUAL ENERGY IMAGING HAS THE POTENTIAL TO ADD NEW AND POWERFUL DIAGNOSTIC CAPABILITIES TO A MEDICAL X-RAY EXAMINATION. UNLIKE AN ORDINARY X-RAY IMAGE, DUAL ENERGY IMAGE DATA CAN BE PROCESSED TO GIVE INFORMATION ABOUT THE CHEMICAL COMPOSITION OF BODY TISSUES. THIS NEW INFORMATION CAN BE USED, FOR EXAMPLE, TO ENHANCE THE DETECTABILITY OF MICROCALCIFICATIONS IN MAMMOGRAPHY OR TO QUANTIFY CALCIUM IN CHEST RADIOGRAPHY. BOTH ARE IMPORTANT DIAGNOSTIC INDICATIONS. IN THE PAST, SPECIALIZED EQUIPMENT WAS NEEDED TO PRODUCE DUAL ENERGY IMAGES. THE INTRODUCTION OF COMPUTED RADIOGRAPHY SYSTEMS FOR USE IN GENERAL RADIOLOGY PROVIDES THE OPPORTUNITY ADDRESSED BY THE WORK. THE LONG-TERM GOAL IS TO DEVELOP AN ENERGY SELECTIVE CASSETTE TO ACQUIRE DUAL ENERGY DATA THAT IS COMPATIBLE WITH THE GENERAL PURPOSE COMPUTED RADIOGRAPHY SYSTEMS. THE CASSETTE WILL USE A UNIQUE APPROACH BASED ON ACTIVE MODULATION OF LUMINESCENCE GAIN INVENTED BY APREND TECHNOLOGY. THIS NEW APPROACH PRODUCES SUBSTANTIALLY HIGHER QUALITY DUAL ENERGY DATA THAN ALTERNATIVE APPROACHES WHILE MAINTAINING COMPATIBILITY WITH GENERAL PURPOSE EQUIPMENT. THE PHASE I WORK WILL SHOW THE FEASIBILITY OF THE APPROACH. IF PHASE I IS SUCCESSFUL, PHASE II WILL BUILD A PROTOTYPE AND TEST IT CLINICALLY.

* information listed above is at the time of submission.

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