AN IMPROVED BLOOD PURIFICATION SYSTEM MAY RESULT FROM A FILTER COMPOSED OF ACTIVATED CHARCOAL IMMOBILIZED IN A POROUS POLYMERIC MATRIX.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3218
Agency Tracking Number:
3218
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
One Maritime Plaza, Suite 1750, San Francisco, CA, 94111
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GASPARD X. CRINER
PRINCIPAL INVESTIGATOR
(415) 433-0489
Business Contact:
() -
Research Institute:
n/a
Abstract
AN IMPROVED BLOOD PURIFICATION SYSTEM MAY RESULT FROM A FILTER COMPOSED OF ACTIVATED CHARCOAL IMMOBILIZED IN A POROUS POLYMERIC MATRIX. THE FILTRATION DEVICE WILL BE FORMULATED SO THAT IT HAS LOW RESISTANCE TO BLOOD FLOW AND DOES NOT CAUSE RED CELL LYSIS. THE POLYMERIC MATRIX WILL ALSO BE CAPABLE OF SUPPORTING IRON CHELATING MATERIALS TO REDUCE IRON OVERLOAD OR ENZYMES WITH CATALYTIC PROPERTIES APPROPRIATE FOR TREATMENT OF SPECIFIC METABOLIC DISORDERS. THIS FEATURE WILL ENHANCE THE PROSPECTS FOR ARTIFICIAL KIDNEY DEVICES BASED ON THESE MATERIALS. THE OBJECTIVE OF THE PROPOSED PHASE I STUDY IS TO EVALUATE THE POTENTIAL OF POLYMERIC MATRICES CONTAINING IMMOBILIZED CHARCOAL TO COMPLEMENT OR REPLACE BLOOD 1. QUANTIFICATION OF DRUG REMOVAL FROM WHOLE BLOOD BY VARIED POLYMERIC MATRICES CONTAINING DIFFERENT TYPES OF CHARCOAL AND 2. QUANTITATION OF THE EFFECT OF THE FILTER ON PLATELET AGGREGATION AND RED CELL FUNCTION (TO INCLUDE ASSAYS OF RED CELL FRAGILITY AND, AFTER FILTRATION, THE OXYGEN BINDING CHARACTERISTICS OF RED CELLS). IT IS ANTICIPATED THAT THESE STUDIES WILL BE FOLLOWED BY A PHASE II EFFORT FOCUSED ON EVALUATION OF IRON REMOVAL AND CORRECTION OF METABOLIC DEFICIENCIES VIA COINCORPORATION OF APPROPRIATE ENZYMES.

* information listed above is at the time of submission.

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