IMPROVEMENTS IN AEROBIC BIOREACTOR CELL CAPACITY THROUGH FACILITATED OXYGEN TRANSPORT AGENTS

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 17275
Amount: $49,993.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
980 Atlantic Ave, Suite 101, Alameda, CA, 94501
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John Kerr
 (415) 521-4331
Business Contact
Phone: () -
Research Institution
N/A
Abstract
BIOREACTOR PROCESSES PRODUCE IMPORTANT PHARMACEUTICALS BUT ARE OFTEN LIMITED FOR COMMERCIAL SCALE-UP BY THE AMOUNT OF OXYGEN IN THE GROWTH MEDIA. ADDITION OF AN OXYGEN-BINDING AGENT TO SOLUTION WILL IMPROVE OXYGEN FLUX RATES AND HENCE INCREASE THE PRODUCTIVITY AND/OR NUMBER OF CELLS PER REACTOR VOLUME. SINCE 1985, THE DEPARTMENT OF DEFENSE HAS CONTRACTED WITH AQUANAUTICS CORPORATION TO DEVELOP AN ARTIFICIAL GILL TECHNOLOGY. THIS PROGRAM DESIGNS AND SYNTHESIZES OXYGEN-BINDING COMPOUNDS WHICH ARE USED IN MANY APPLICATIONS. FOR PHASE I, AQUANAUTICS PROPOSES TO EXPLOIT THESE COMPOUNDS AS AGENTS TO FACILITATE OXYGEN FLUX TO MAMMALIAN HYBRIDOMA CELLS AND IN GROWTH MEDIA. RESEARCH WOULD DEMONSTRATE VIABILITY OF THE AGENTS IN SOLUTION AND THE LEVEL OF ENHANCED CELL DENSITY ON THE EFFECT ON AEROBIC METABOLISM AND PRODUCTIVITY. AQUANAUTICS HAS DEMONSTRATED DRAMATIC TECHNICAL ADVANCEMENTSWITH A TEAM OF 10 PROFESSIONALS, OF WHOM 5 HOLD PH.D. DEGREES. NSF CAN DEVELOP THIS TECHNOLOGY WITH ONLY AN INCREMENTAL INVESTMENT BECAUSE AQUANAUTICS HAS INVESTED MORE THAN *10 MILLION IN THIS TECHNOLOGY. THE COMPANY HAS SBIR EXPERIENCE AND THE FACILITIES TO CONDUCT THE SCOPE OF WORK.

* Information listed above is at the time of submission. *

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