BioPhalanx, a hand portable discrete monolithic microarray biothreat detector

Award Information
Agency:
Department of Homeland Security
Branch
n/a
Amount:
$100,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
NBCHC060031
Agency Tracking Number:
#0521268
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Arcxis Biotechnologies
18858 Carlton Avenue, Castro Valley, CA, 94546
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Jay West
Acting CTO
(925) 989-7496
Business Contact:
Jay West
Acting CTO and consultant
(925) 989-7496
khukari@arcxis.com
Research Institution:
n/a
Abstract
The focus of this proposal is to develop BioPhalanx a rapid, hand portable, robust detection system for multiplexed detection of bio-threats, in harsh environments. We have developed a new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability. This type of analysis will greatly reduce false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. The Arcxis Biotechnologies team has realized specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM). We have further developed the ability to perform rapid and complete solubilisation of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilisation protocol. Combining these proprietary technologies provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The BioPhalanx system is designed to perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. In all, the proposed BioPhalanx system is robust, simple to use, and addresses the goals of DHS and the first responder community.

* information listed above is at the time of submission.

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