Instrumentation for Monitoring Breath Biomarkers for Diagnosis of Health, Condition, Toxic Exposure, and Disease

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA9550-04-C-0137
Agency Tracking Number: F045-017-0081
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2004
Solicitation Year: 2004
Solicitation Topic Code: AF04-T017
Solicitation Number: N/A
Small Business Information
P.O. Box 6024, Sherman Oaks, CA, 91413
DUNS: 082191198
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory J Fetzer
 Deputy Division Director
 (520) 571-8660
 gfetzer@arete-az.com
Business Contact
 Patrick Manzo
Title: Vice President
Phone: (520) 571-8660
Email: pmanzo@arete.com
Research Institution
 National Heart lung & Blood Institu
 Ephraim Johnson
 Building 31, Room 5A52, 31 Center Drive MSC 2486
Bethesda, MD, 20892
 (301) 594-9529
 Domestic nonprofit research organization
Abstract
Arete Associates and National Jewish Medical and Research Center propose to develop an instrument to measure the concentration of ethane in exhaled breath. The analyzer uses the combination of a proprietary hollow optical waveguide measurement cell, tunable semiconductor laser, and wavelength modulation spectroscopy to provide sensitive and reliable measurements of ethane. The sensor will exhibit rapid response time (<1s), low minimum detection limits (100's of parts per trillion) and will be physically compact relative to other sensors with similar sensitivity. The proposed project leverages our experience developing a mid infrared laser absorption spectrometer (MIRLAS) to monitor NO in exhaled breath. In Phase I, a benchtop measurement system will be constructed and tested. This system will be challenged with a variety of laboratory air mixtures. Phase II will consist of the development and optimization of a prototype instrument that will be used to monitor both NO and ethane in research trials with human subjects at NJMRC. Ethane and NO measurements will be verified using gas chromatographic and chemiluminescence techniques respectively.

* Information listed above is at the time of submission. *

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