Instrumentation for Monitoring Breath Biomarkers for Diagnosis of Health, Condition, Toxic Exposure, and Disease

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2004
Program:
STTR
Phase:
Phase I
Contract:
FA9550-04-C-0137
Agency Tracking Number:
F045-017-0081
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ARETE ASSOC.
P.O. Box 6024, Sherman Oaks, CA, 91413
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
082191198
Principal Investigator:
Gregory Fetzer
Deputy Division Director
(520) 571-8660
gfetzer@arete-az.com
Business Contact:
Patrick Manzo
Vice President
(520) 571-8660
pmanzo@arete.com
Research Institution:
National Heart lung & Blood Institu
Ephraim Johnson
Building 31, Room 5A52, 31 Center Drive MSC 2486
Bethesda, MD, 20892
(301) 594-9529
Domestic nonprofit research organization
Abstract
Arete Associates and National Jewish Medical and Research Center propose to develop an instrument to measure the concentration of ethane in exhaled breath. The analyzer uses the combination of a proprietary hollow optical waveguide measurement cell, tunable semiconductor laser, and wavelength modulation spectroscopy to provide sensitive and reliable measurements of ethane. The sensor will exhibit rapid response time (<1s), low minimum detection limits (100's of parts per trillion) and will be physically compact relative to other sensors with similar sensitivity. The proposed project leverages our experience developing a mid infrared laser absorption spectrometer (MIRLAS) to monitor NO in exhaled breath. In Phase I, a benchtop measurement system will be constructed and tested. This system will be challenged with a variety of laboratory air mixtures. Phase II will consist of the development and optimization of a prototype instrument that will be used to monitor both NO and ethane in research trials with human subjects at NJMRC. Ethane and NO measurements will be verified using gas chromatographic and chemiluminescence techniques respectively.

* information listed above is at the time of submission.

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