Cartilage Repair by Engineered Implant Feasibility study

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
1R43AR048470-01A2
Agency Tracking Number:
AR048470
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ARTICULAR ENGINEERING, LLC
ARTICULAR ENGINEERING, LLC, 1818 SKOKIE BLVD, STE 158, NORTHBROOK, IL, 60062
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BRIAN PFISTER
(847) 498-9634
BPFISTER@ARTICULAR.COM
Business Contact:
MICHAEL HEJNA
(847) 498-9634
MHEJNA@ARTICULAR.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): This small business Innovation Research Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue. Recent studies have demonstrated that the alginate recovered chondrocyte (ARC) method can be used to stimulate isolated adult articular chondrocytes in vitro to form viable cartilaginous tissue with good physiochemical properties. The purpose of this proposal is to define ARC culture conditions for the in vitro formation of pig cartilage tissue. ARC tissue produced in vitro will first be analyzed to determine the biochemical composition, histological appearance and functional properties. Then, the tissue will then be transplanted into full-thickness defects in articular cartilage of adult pigs. At a single time point after transplantation the biochemical composition, histological appearance and functional properties will again be assessed and related to a control defect and initial values. The data will be utilized to determine the feasibility of using the ARC method for the repair of injured or diseased cartilage tissue. Feasibility will be determined by pre-defined criteria related to the assessment of integration, maturation and functional properties after implantation. The proposed research will ideally lead to a commercial method of production of engineered tissue for surgical implantation to repair defects of articular cartilage in humans.

* information listed above is at the time of submission.

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