UREA MONITORING DURING DIALYSIS WITH THE BIOLOGIC-HD

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7983
Agency Tracking Number:
7983
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2701 B Kent Ave, West Lafayette, IN, 47906
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
WE HAVE DEVELOPED A DIALYSIS SYSTEM WHICH IS SIMPLE, SAFE, AND PORTABLE. THE BIOLOGIC-HD SYSTEM IS A SINGLE ACCESS, SORBENT BASED DIALYSIS SYSTEM WITH RECENTLY DEVELOPED MONITORS TO DETERMINE: TOTAL WEIGHT REMOVAL, BLOOD FLOW RATE, CLOTTING OF THE DIALYZER, AND COLUMN SATURATION (A CONTINUALLY OPERATING AMMONIUM MONITOR). THE AMMONIUM MONITOR CONTAINS A GAS-PERMEABLE MEMBRANE WHICH ALLOWS PASSAGE OF AMMONIUM INTO A PH SENSITIVE STRIP. A REFLECTANCE PHOTOMETER MEASURES COLOR CHANGE OF THE STRIP DURING DIALYSIS. WE NOW PROPOSE TO MODIFY THIS AMMONIUM MONITOR BY ADDING A UREASE-CONTAINING STRIP IN FRONT OF THE GAS-PERMEABLE MEMBRANE. THE AMMONIUM GENERATION AND COLOR CHANGE OF THE MONITOR WILL BE PROPORTIONAL TO THE UREA LEVEL. THE COMPUTERS IN THE MACHINE WILL DETERMINE THE APPROXIMATE BLOOD CONCENTRATION OF UREA BY APPLYING FORMULASINCLUDING BLOOD FLOW RATE AND THE DIALYSANCE OF THE DIALYZER. THE MACHINE WILL THEN BE ABLE TO DISPLAY: TIME OF COMPLETION OF AN EFFICIENT DIALYSIS (A 58% DROP IN BUN, EQUAL TO A KT/V=1), PROBABILITY OF SATURATING THE SORB COLUMN DURING THE TREATMENT, AND COMPARISON OF CHEMICAL PROCESS TO THAT EXPECTED FOR THIS PATIENT (KT/V=1). THE CHEMICAL RESULTS OF EACH TREATMENT WILL BE USED TO SUGGEST PROPER SETTINGS OF THE MACHINE FOR THE NEXT DIALYSIS OF THE PATIENT, AND CHEMICAL EFFECT OF TREATMENT WILL BE TRANSFERRED TO THE SMARTCHART(R) CLINICAL INFORMATION SYSTEM. DURING THIS PROJECT, THE MONITOR WILL BE CONSTRUCTED, TESTED IN VITRO, AND INFORMATION TRANSFER AND INTERPRETATION ALGORIAHMS COMPLETED AND TESTED.

* information listed above is at the time of submission.

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