Aptamer-based Nanofunctionalized OFET Biosensor

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-15-M-5095
Agency Tracking Number: F14A-T11-0051
Amount: $150,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: AF14-AT11
Solicitation Number: 2014.1
Timeline
Solicitation Year: 2014
Award Year: 2015
Award Start Date (Proposal Award Date): 2014-11-13
Award End Date (Contract End Date): 2015-11-13
Small Business Information
2750 Indian Ripple Road, Dayton, OH, 45440
DUNS: 000000000
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Brian Henslee
 (937) 320-1877
 hensleeb@crgrp.com
Business Contact
 Stephen D Vining
Title: Dr.
Phone: (937) 320-1877
Email: viningsd@crgrp.net
Research Institution
 Leland Stanford Junior University
 Brian Del Bono
 3160 Porter Drive, Suite 100
Palo Alto, CA, 94304-8445
 (650) 725-8109
 Nonprofit college or university
Abstract
ABSTRACT: Physiological and environmental monitoring and telemedicine are becoming important tools. Biomarkers play an important role in diagnosing health conditions and enabling advanced care and monitoring systems implemented through telemedicine. Telemedicine tools are needed to seamlessly interface and communicate the physiological condition of the human body with modern electronics including computers and cell networks. CRG proposes to provide an affordable, continuous, non-invasive sensor with electronic output to enable new biomarkers to impact telemedicine. To gain the specificity and selectivity that is needed for biomarker detection in bodily fluids CRG and Stanford propose an organic field effect (OFET) aptamer-based sensor. Stanfords OFETs are water stable and capable of detecting biomolecules via aptamers conjugated to nanoparticles on the semiconductor surface. Nanoparticle based functionalization limits aptamer binding sites and higher loadings of aptamer can potentially increase OFET performance. Nanowires, nanotubes, or nanofibers can provide greater surface area for aptamer conjugation and leading to greater sensitivity. CRG and Stanfords OFET biosensor concept contains aptamers conjugated to nanomaterials on a water stable OFET platform to create the Aptamer-based Nanofunctionalized OFET biosensor. This biosensor is wrapped in a micro-fluidic platform for direct detection of biomarkers in liquid media including sweat, saliva, or serum. ; BENEFIT: Operational Benefits: (1) Improved OFET performance, (2) Water stable, (3) Capable of detection at low limits, (4) Reduced variability between devices, and (5) Long term stability and operational re-use Commercial Applications: (1) Environmental monitoring, (2) Multiplex healthcare diagnostics, and (3) Point of care diagnostics

* Information listed above is at the time of submission. *

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