DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR A MURINE CYTOKINE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
16565
Agency Tracking Number:
16565
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
335 Paint Branch Drive, College Park, MD, 20742
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Tamarkin, Lawrence
Principal Investigator
(301) 445-4220
Business Contact:
1 N43 DK12276-00
() -
Research Institute:
n/a
Abstract
UNDERSTANDING THE INTERACTIONS OF THE CYTOKINES OF THE IMMUNE SYSTEM IN THE REGULATION OF THE IMMUNE CASCADE DURING THE HOST- DEFENSE MECHANISM IS OF INTENSE SCIENTIFIC INTEREST (1-2). NEWLY EMERGING RESEARCH ALSO DEMONSTRATE THAT SOME OF THESE MOLECULES ACT IN AN ENDOCRINE FASHION OUTSIDE THE IMMUNE SYSTEM (3-8). EXAMINING THESE MOLECULES AS CIRCULATING ENDOCRINE COMMUNICATING SIGNALS OFFERS NEW SCIENTIFIC CHALLENGES, BUT THIS CHALLENGE HAS BEEN ESSENTIALLY THWARTED BY THE LACK OF SIMPLE, RELIABLE ASSAY SYSTEMS TO EVALUATE THESE MOLECULES IN BIOLOGIC FLUIDS OF EXPERIMENTAL ANIMALS. ALTHOUGH SOME ASSAYS EXIST FOR MONITORING HUMAN CYTOKINES, LITTLE OR NO ATTENTION HAS BEEN FOCUSED ON SUPPORTING BASIC CYTOKINE RESEARCH WITH ANALYTICAL SYSTEMS THAT EVALUATE MURINE CYTOKINES IN CULTURE MEDIA, AS WELL AS SERUM. THE SHORT-TERM GOAL IS TO DEVELOP AN ENZYME IMMUNOASSAY TO MEASURE THE MURINE CYTOKINE, INTERLEUKIN 6, HOWEVER, THE LONG-TERM GOAL IS TO DEVELOP A COMPLETE BATTERY OF MURINE CYTOKINE ENZYME IMMUNOASSAYS.

* information listed above is at the time of submission.

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