HAND-HELD DIAGNOSTIC FOR THE DETECTION OF AUTOANTIBODIES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19212
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
335 Paint Branch Drive, College Park, MD, 20742
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Lawrence Tamarkin
 (301) 445-4220
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DETECTION OF AUTOANTIBODIES IN THE LIVER DISEASES PBC, PSC AND CAH MAY SERVE AS A DIAGNOSTIC IN ASSESSING THE SEVERITY AND/OR PROGRESSION OF DISEASE. IN PHASE I WE PLAN TO DEVELOP ENZYME-BASED IMMUNOASSAYS (EIAS) FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PBC. WE PLAN TO USE THE RECOMBINANTLY ENGINEERED MOLECULE "PDC-E2/BCOADH-E2" WHICH CONTAINS THE ANTIGENIC DETERMINANATS FOR THE TWO CLASSES OF AUTOANATIBODIES ASSOCIATED WITH PBC AS THE DETECTION ANTIGEN. INITIALLY, WE WILL GENERATE A PLATE-BASED EIA OFFERING BOTH POSITIVE AND NEGATIVE CONTROLS FOR COMPARISON. UPON SUCCESSFUL COMPLETION OF THIS TASK, WE WILL, USING THE DESIGNER MOLECULE, DEVELOP A HAND-HELD DIAGNOSTIC FOR DETECTING THE AUTOANTIBODIES ASSOCIATED WITH PBC. THE HAND-HELD EIA, WILL BE A QUICK, SIMPLE SYSTEM WHICH COULD BE PERFORMED IN THE HOSPITAL AT THE PATIENT'S BEDSIDE OR IN A PHYSICIAN'S OFFICE. THE DATA FROM THE SUCCESSFUL COMPLETION OF THIS TASK WOULD THEN SERVE AS THE TECHNICAL BASE FOR THE DEVELOPMENT OF HAND-HELD EIAS FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PSC, AND CAH, AS WELL AS OTHER AUTOIMMUNE DISORDERS.

* Information listed above is at the time of submission. *

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