HAND-HELD DIAGNOSTIC FOR THE DETECTION OF AUTOANTIBODIES

Award Information
Agency:
Department of Health and Human Services
Amount:
$50,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1992
Phase:
Phase I
Agency Tracking Number:
19212
Solicitation Topic Code:
N/A
Small Business Information
Assay Research Inc
335 Paint Branch Drive, College Park, MD, 20742
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Lawrence Tamarkin
 (301) 445-4220
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DETECTION OF AUTOANTIBODIES IN THE LIVER DISEASES PBC, PSC AND CAH MAY SERVE AS A DIAGNOSTIC IN ASSESSING THE SEVERITY AND/OR PROGRESSION OF DISEASE. IN PHASE I WE PLAN TO DEVELOP ENZYME-BASED IMMUNOASSAYS (EIAS) FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PBC. WE PLAN TO USE THE RECOMBINANTLY ENGINEERED MOLECULE "PDC-E2/BCOADH-E2" WHICH CONTAINS THE ANTIGENIC DETERMINANATS FOR THE TWO CLASSES OF AUTOANATIBODIES ASSOCIATED WITH PBC AS THE DETECTION ANTIGEN. INITIALLY, WE WILL GENERATE A PLATE-BASED EIA OFFERING BOTH POSITIVE AND NEGATIVE CONTROLS FOR COMPARISON. UPON SUCCESSFUL COMPLETION OF THIS TASK, WE WILL, USING THE DESIGNER MOLECULE, DEVELOP A HAND-HELD DIAGNOSTIC FOR DETECTING THE AUTOANTIBODIES ASSOCIATED WITH PBC. THE HAND-HELD EIA, WILL BE A QUICK, SIMPLE SYSTEM WHICH COULD BE PERFORMED IN THE HOSPITAL AT THE PATIENT'S BEDSIDE OR IN A PHYSICIAN'S OFFICE. THE DATA FROM THE SUCCESSFUL COMPLETION OF THIS TASK WOULD THEN SERVE AS THE TECHNICAL BASE FOR THE DEVELOPMENT OF HAND-HELD EIAS FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PSC, AND CAH, AS WELL AS OTHER AUTOIMMUNE DISORDERS.

* information listed above is at the time of submission.

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