Intracranial Brain Function Mapping System

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS046121-01
Agency Tracking Number: NS046121
Amount: $107,050.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (610) 825-4555
Business Contact
Phone: (610) 825-4555
Research Institution
DESCRIPTION (provided by applicant): A computer controlled switching stimulator/amplifier is proposed which is capable of delivering electrical stimuli between pairs of intracranial electrodes, while simultaneously monitoring the EEG potentials on all implanted electrodes immediately before and after stimulus application In phase 1, a key feasibility issue will be to study the electro-chemical effects that that leave residual potentials on the electrodes immediately after stimulation which can block viewing the EEG. The knowledge gained will be used to build a breadboard EEG amplifier-stimulus generator combination which will permit recording and observation of the EEG in the stimulated channel as soon as possible after termination of the stimulus waveform train. Phase 2 will have the specific aim of embodying the design into a marketable product capable of expansion to at least 128 channels. Two 128 channel systems will be built. The developed hardware and software will be beta tested using human subjects who would normally be scheduled for clinical functional mapping prior to resective brain surgery for epilepsy. The technology developed will also be useful for brain functional mapping preceding other resective surgery such as for tumors.

* information listed above is at the time of submission.

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