IDENTIFICATION OF ALZHEIMER-SPECIFIC ANTIGENS IN CSF

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
11355
Agency Tracking Number:
11355
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
800f Gateway Blvd, S San Francisco, CA, 94080
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS RESEARCH IS TO DEFINE ANTIGENS IN THE CEREBROSPINAL FLUID (CSF) THAT ARE SPECIFIC TO ALZHEIMER'S DISEASE. ULTIMATELY, THE POTENTIAL RESULTS OF THIS EFFORT MAY BE THE DEVELOPMENT OF A CSF-BASED DIAGNOSTIC IMMUNOASSAYFOR USE BOTH AS A DIAGNOSTIC MARKER AND AS A USEFUL ADJUNCT TO MONITOR EVENTUAL THERAPY. THE METHODOLOGY TO IDENTIFY THE DIAGNOSTIC MARKERS INVOLVES THE SCREENING OF A LARGE NUMBER OF MONOCLONAL ANTIBODIES WITH A HIGHLY SENSITIVE AND PREDICTIVE FLUOROMETRIC TEST. THE ASSAY IS CONFIGURED IN SUCH A WAY THAT ONLY MONOCLONAL ANTIBODIES OF DIAGNOSTIC POTENTIAL ARE IDENTIFIED. IN ADDITION, THE IMMUNOGENS THAT ARE TO BE USED ARE THOSE RELATED DIRECTLY TO THE DISEASE. THUS, THE RESEARCH PLAN BRINGS TOGETHER MACROMOLECULES KNOWNTO BE INVOLVED IN ALZHEIMER'S DISEASE WITH A SENSITIVE, HIGH-VOLUME SCREEN CAPABLE OF DETECTING ANTIBODIES OF DIAGNOSTIC POTENTIAL. THE ULTIMATE GOAL OF THE RESEARCH PLAN WILL BE TO IMMUNOAFFINITY PURIFY AND STRUCTURALLY CHARACTERIZE ANTIGENS THAT ARE SPECIFICALLY ELEVATED IN ALZHEIMER'S DISEASE.

* information listed above is at the time of submission.

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