Open Topic Search

Background Currently there is no cost effective tool which enables researchers to study drug addiction relapse in real time. The standard remains to be urine analysis or self-report/surveys. Unfortunately, depending on the drug, urine analysis can only detect recent drug use in the previous 24 to 72 hours. Even in the best case scenario and based on lab assay results, the associated intervention r ...

Section I. Funding Opportunity Description    Less than 2% of small molecule pharmacotherapeutics effectively cross the blood brain barrier (BBB) . Larger molecules, such as peptides or antibodies, are virtually impenetrable. Direct routes of administration (e.g., epidural-, intracerebral- or intracerebral ventricular delivery) are invasive, costly and impractical for repeated dosing int ...

Section I. Funding Opportunity Description  Less than 2% of small molecule pharmacotherapeutics effectively cross the blood brain barrier (BBB). Larger molecules, such as peptides or antibodies, are virtually impenetrable. Direct routes of administration (e.g., epidural-, intracerebral- or intracerebral ventricular delivery) are invasive, costly and impractical for repeated dosing into the CN ...

Purpose This Funding Opportunity Announcement (FOA)  seeks R43/R44 SBIR grant applications from small businesses to develop novel technologies that will enable at least one order of magnitude improvement in DNA sequencing, and practical methods for direct RNA sequencing.  Advances in genomics and more broadly in biomedical research have been greatly facilitated by significant and sustain ...

Purpose To facilitate the cooperation and partnering of public and private funding organizations, universities, academic medical centers, research institutes, contract research organizations, biotechnology companies, and pharmaceutical companies in the advancement of interventions for stroke prevention, treatment, and rehabilitation, NINDS has formed the NIH Stroke Clinical Trials Research Netwo ...

Several U.S. government sponsored programs, including the U.S. Tox21 program (http://ntp.niehs.nih.gov/go/tox21) and the U.S. EPA’s ToxCast program (http://www.epa.gov/ncct/toxcast/), were developed to expand the scope and throughput of screening compounds for toxicity. A primary focus of these programs is on the use of in vitro methods and assays using lower organisms to screen thousands of ...

Contact Dr. Charles Cleland, NPL for SBIR Forests and Related Resources at ccleland@nifa.usda.gov or (202) 401-6852 regarding questions about the topic area or to arrange a telephone consultation. Background The Forests and Related Resources topic area aims to address the health, diversity and productivity of the Nation’s forests and grasslands to meet the needs of present and future generations ...

Contact Dr. Robert Nowierski, NPL for SBIR Plant Production and Protection - Biology at rnowierski@nifa.usda.gov or (202)401-4900 regarding questions about the suitability of research topics or to arrange a telephone consultation. Background The objective of this topic area is to examine novel ways of enhancing crop production and protection by applying biological approaches to develop new met ...

Contact Dr. Robert Smith, NPL for SBIR Animal Production and Protection at rsmith@nifa.usda.gov or (202) 401-4892 regarding questions about the topic area or to arrange a telephone consultation. Background The Food and Agriculture Organization (FAO) of the United Nations predicts that feeding the world’s growing population will require a doubling of global food production by 2050. Fulfil ...

Contact Dr. Karelyn Cruz, National Program Leader for SBIR Air, Water and Soils at karelyn.cruz@nifa.usda.gov or (202) 604-7742 regarding questions about the topic area or to arrange a telephone consultation. Background The Air, Water and Soils topic area aims to develop and commercialize technologies and innovations for conserving, monitoring and protecting air, water and soil resources while sus ...