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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DK-19-028 : Support for Small Business Innovation Research (SBIR) to Development and Testing of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-10-2019Open Date: 03-09-2020 Due Dates: Multiple Close Date: 11-03-2020

    Purpose and Research Objectives: Despite clear progress made during the last 15 years on cellular transplantation for T1D, the most recent results demonstrate a long-term limited viability of engrafted islets and, as a result, limited insulin independence under different novel modalities of immunosuppressive (IS) regimens tested. In addition, even the most innovative IS regimens required for tran ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-AG-21-026 : Preclinical Development of Novel Therapeutics Targeting Aging Mechanisms (SBIR U44 Clinical Trial Not Allowed)

    Release Date: 06-25-2020Open Date: 10-10-2020Due Date: 11-10-2020Close Date: 11-11-2020

    Background Recent health statistics indicate that the prevalence of multiple chronic conditions (two or more) in the United States is 50% among individuals age 45-64 years and 81% among individuals age 65 years and older. Examples of chronic conditions include diabetes, arthritis, chronic obstructive pulmonary disease (COPD), heart disease, cancer, stroke, and dementia and other cognitive impairm ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-AG-21-025 : Development of Cost-Effective and Customizable Training and Education Platforms for AD/ADRD Caregivers that Focus on Addressing Financial Management and Legal Planning (R43/R44 Clinical Trial Not Allowed)

    Release Date: 05-27-2020Open Date: 10-12-2020Due Date: 11-12-2020Close Date: 11-13-2020

    There is a fundamental need for the development of technologies that enhance caregiver training and address the financial and legal aspects of caregiving. By the close of this decade, the number of family caregivers of adults is expected to increase to 45 million, while the number of individuals potentially requiring care is anticipated to reach 117 million. In 2013 alone, approximately 37 billion ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-TR-20-031: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 09-15-2020Open Date: 10-12-2020Due Date: 11-12-2020Close Date: 11-13-2020

    A. Overview While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underly multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecu ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. R: LOwering CO2: Models to Optimize Train Infrastructure, Vehicles, and Energy Storage (LOCOMOTIVES)

    Release Date: 09-23-2020Open Date: 09-23-2020Due Date: 11-23-2020Close Date: 11-23-2020

    Through this LOCOMOTIVES Topic, ARPA-E seeks the development of validated planning and simulation tools that are able to model the deployment of a wide range of ES technologies in the Class 1 Rail Freight sector and that determine associated lifecycle GHG emissions and levelized cost of Mt-km (LCOTKM) values over various time scales (e.g., 10, 20, 30 years). ARPA-E seeks the development of these t ...

    SBIR/STTRPhase I/Phase IIDepartment of EnergyARPA-E
  6. M: Advanced Manufacturing (M)

    Release Date: 12-18-2019Open Date: 12-18-2019 Due Dates: Multiple Close Date: 12-03-2020

    The Advanced Manufacturing topic aims to support emerging innovations in manufacturing with the potential to stimulate the nation’s manufacturing sector by improving its efficiency, competitiveness, and sustainability. Proposed technology should be environmentally friendly, compatible with human health and planet health, and driven by technological advancements. Examples include, but are not lim ...

    STTRPhase INational Science Foundation
  7. M1: Additive Manufacturing Components and Systems

    Release Date: 12-18-2019Open Date: 12-18-2019 Due Dates: Multiple Close Date: 12-03-2020

    M1 NSF STTR Phase I (2020) National Science Foundation ...

    STTRPhase INational Science Foundation
  8. M2: Bio-Inspired Manufacturing

    Release Date: 12-18-2019Open Date: 12-18-2019 Due Dates: Multiple Close Date: 12-03-2020

    M2 NSF STTR Phase I (2020) National Science Foundation ...

    STTRPhase INational Science Foundation
  9. M3: Cybermanufacturing

    Release Date: 12-18-2019Open Date: 12-18-2019 Due Dates: Multiple Close Date: 12-03-2020

    M3 NSF STTR Phase I (2020) National Science Foundation ...

    STTRPhase INational Science Foundation
  10. M4: Human-Centric Industrial Technologies

    Release Date: 12-18-2019Open Date: 12-18-2019 Due Dates: Multiple Close Date: 12-03-2020

    M4 NSF STTR Phase I (2020) National Science Foundation ...

    STTRPhase INational Science Foundation
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