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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-AG-23-029: NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional)

    Release Date: 07-06-2022Open Date: 01-17-2023Due Date: 02-17-2023Close Date: 02-18-2023

    The number of available tenure-track faculty positions has not kept pace with the growing number of Ph.D. graduates in recent years. This imbalance has created a highly competitive job environment, making it increasingly difficult for Ph.D. graduates to transition to academic appointments. Doctoral and post-doctoral training programs have heavily revolved around developing skill sets that are dire ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAS-22-196: Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

    Release Date: 06-21-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-08-2025

    Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and development proposals which, if pursued, have the potential to reduce the human burden and healthcare costs associated with AD/ADRD. As part of t ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-NS-23-006: HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)

    Release Date: 09-15-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 04-05-2025

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PAR-23-032: Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)

    Release Date: 10-27-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-05-2025

    Purpose This Funding Opportunity Announcement (FOA) encourages the translation of technology and therapeutic innovations from academic and other non-profit research sectors to the marketplace to advance the development of diagnostic and prevention tools or treatments for musculoskeletal, rheumatic, or skin diseases. Small Business Concerns (SBCs) are encouraged to apply for this Small Business In ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. RFA-TR-22-032: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44- Clinical Trail Not Allowed)

    Release Date: 09-19-2022Open Date: 10-21-2022 Due Dates: Multiple Close Date: 08-22-2023

    Section I. Funding Opportunity Description This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR)Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. HHS-2023-ACL-NIDILRR-BISA-0000: Small Business Innovation Research (SBIR) program, Phase I

    Release Date: 10-17-2022Open Date: 10-17-2022Due Date: 12-16-2022Close Date: 12-16-2022

    NIDILRR¡¦s mission is to generate new knowledge and to promote its effective use to improve the abilities of individuals with disabilities to perform activities of their choice in the community and to expand society¡¦s capacity to provide full opportunities and accommodations for its citizens with disabilities. All SBIR projects funded by NIDILRR must address the needs of individuals with disa ...

    SBIRPhase IDepartment of Health and Human ServicesAdministration for Community Living
  7. C55-01: ACCELERATING THE DEPLOYMENT OF ADVANCED SOFTWARE TECHNOLOGIES

    Release Date: 09-29-2022Open Date: 09-29-2022Due Date: 12-31-2022Close Date: 12-31-2022

    Deployment of ASCR-Funded Software Integration of ASCR-Funded Libraries Other C55-01 FY2023 Phase I Release 1 Department of Energy ...

    SBIR/STTRPhase IDepartment of Energy
  8. C55-02: HPC CYBERSECURITY

    Release Date: 09-29-2022Open Date: 09-29-2022Due Date: 12-31-2022Close Date: 12-31-2022

    Cybersecurity Technologies Other C55-02 FY2023 Phase I Release 1 Department of Energy ...

    SBIR/STTRPhase IDepartment of Energy
  9. C55-03: DIGITAL TWIN CAPABILITIES FOR SCIENCE NETWORK INFRASTRUCTURES

    Release Date: 09-29-2022Open Date: 09-29-2022Due Date: 12-31-2022Close Date: 12-31-2022

    Network Simulation Tools Other C55-03 FY2023 Phase I Release 1 Department of Energy ...

    SBIR/STTRPhase IDepartment of Energy
  10. C55-04: TECHNOLOGY TO FACILITATE THE USE OF NEAR-TERM QUANTUM COMPUTING HARDWARE

    Release Date: 09-29-2022Open Date: 09-29-2022Due Date: 12-31-2022Close Date: 12-31-2022

    Software for Calibration, Characterization, and Control of Quantum Processors Ultra-Low-Loss Integration of Heterogeneous Quantum Internet Devices C55-04 FY2023 Phase I Release 1 Department of Energy ...

    SBIR/STTRPhase IDepartment of Energy
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