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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAS-22-196: Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

    Release Date: 06-21-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-08-2025

    Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and development proposals which, if pursued, have the potential to reduce the human burden and healthcare costs associated with AD/ADRD. As part of t ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. AF231-0012: ADV MMW RAM (Advanced Millimeter-Wave Radar Absorbing Materials)

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dua ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  3. AF231-D011: AI for Systems Engineering Assessment Model (SEAM) activities

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which control ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  4. PAR-21-057: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 11-19-2020Open Date: 01-22-2021 Due Dates: Multiple Close Date: 09-08-2023

    Background A biomarker is a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints, as well as composite biomarkers or biomarker signatures. Becaus ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. AF231-0001: APTU Combustion Health Monitoring

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Hypersonics The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use i ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  6. AF231-0016: ATC for Small CTKs

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy OBJECTIVE: Develop a technology assisted, portable, ruggedized, toolbox for use in all-weather maintenance environments that can be 3D printed DESCRIPTION: Technicians currently rely on manual accountability for tools and equipment - all accountability is hand-recorded. Additionally, inspections and tool replacement uses human judge ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  7. AF231-0015: ATC Kit

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy OBJECTIVE: Develop a technology to convert mobile/rolling toolboxes (of various sizes and drawer quantities) into automated inventory assisted toolboxes. In other words, develop a sensor suite capable of being applied to any mobile toolbox converting it into an automated inventory toolbox. DESCRIPTION: Technicians currently rely on ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  8. AF231-0018: Automated Sourcing Supply

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy; Integrated Network Systems-of-Systems OBJECTIVE: Develop an automated sourcing supply solution that is compatible with DoD information systems and other developmental technology to bridge current Air Force maintenance operations and logistic systems. The system needs to automatically predict and automatically order a broad range of ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  9. RFA-TR-22-029: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 07-13-2022Open Date: 07-18-2022 Due Dates: Multiple Close Date: 07-13-2023

    A. Overview While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underlie multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molec ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. DLA231-D06: Battery Management System Cybersecurity Verification System

    Release Date: 01-11-2023Open Date: 02-08-2023Due Date: 03-08-2023Close Date: 03-08-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which co ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
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