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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DA-24-018: Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R43/R44 Clinical Trial Optional)

    Release Date: 05-24-2023Open Date: 10-09-2023Due Date: 11-10-2023Close Date: 11-11-2023

    In 2020, 40.3 million people aged 12 or older had substance use disorder (SUD) in the past year. Of those, 2.6 million people (6.4%) received any in-person treatment, while 2.2 million (5.4%) received virtual services for substance use treatment. Therefore, an estimated 35 million people did not receive any treatment. To receive treatment, individuals need to receive a diagnosis from a provider, ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-DA-24-017: Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R41/R42 Clinical Trial Optional)

    Release Date: 05-24-2023Open Date: 10-09-2023Due Date: 11-09-2023Close Date: 11-10-2023

    In 2020, 40.3 million people aged 12 or older had substance use disorder (SUD) in the past year. Of those, 2.6 million people (6.4%) received any in-person treatment, while 2.2 million (5.4%) received virtual services for substance use treatment. Therefore, an estimated 35 million people did not receive any treatment. To receive treatment, individuals need to receive a diagnosis from a provider, ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-CA-23-034: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 04-21-2023Open Date: 07-21-2023Due Date: 08-21-2023Close Date: 08-22-2023

    Purpose The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medic ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-CA-23-035: Small Business Transition Grant For Early Career Scientists (R42 Clinical Trial Not Allowed)

    Release Date: 04-21-2023Open Date: 07-21-2023Due Date: 08-21-2023Close Date: 08-22-2023

    Purpose Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), and National Institute on Drug Abuse (NIDA) intend to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technology from academic laboratories into small busin ...

    SBIR/STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. RFA-ES-23-005: SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

    Release Date: 03-03-2023Open Date: 06-14-2023Due Date: 07-14-2023Close Date: 07-15-2023

    This SBIR Funding Opportunity Announcement (FOA) focuses on the development of e-Learning health and safety training products from a variety of delivery methods to assist both students and instructors in the training and education process. Note that all products must be directly related to the health and safety training of workers exposed to hazardous materials (HAZMAT). Workers that may be expose ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-ES-23-008: Novel Approaches for Developmental Neurotoxicity Testing (R43/R44 Clinical Trial Not Allowed)

    Release Date: 03-21-2023Open Date: 06-07-2023Due Date: 07-07-2023Close Date: 07-08-2023

    Background Worldwide prevalence of learning and behavioral disabilities and neurodevelopmental disorders such as autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD) in children are on the rise. Associations between chemical exposures during development and neurodevelopmental disorders leading to cognitive and psychiatric outcomes has been reported. Due to concerns that t ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. OSD232-001: Application-Specific Photonic Integrated Circuit (PIC) for a Quantum System

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Quantum Science OBJECTIVE: Develop an application-specific photonic integrated circuit to serve a specific quantum system (e.g. Rydberg sensor, clock transition). The device should integrate into and be demonstrated with an already existing quantum sensor. DESCRIPTION: Quantum sensors have demonstrated the ability to surpass classical sensors in areas such ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  8. OSD232-D02: Manufacturable High-Performance Magnetometers

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Biotechnology; Quantum Science The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  9. OSD232-003: Efficient Integration or Direct Growth on SOI of Foundry-Scale CMOS Compatible Second Order Nonlinear Materials and/or Short-Wavelength Photonic Materials with Low Optical Loss

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Quantum Science OBJECTIVE: Development of a foundry-compatible, direct growth in a Silicon on insulator (SOI) stack, second-order nonlinear material that can be that can be used for photon conversion and low loss waveguides. DESCRIPTION: Silicon on insulator (SOI) has been a growing standard platform for foundry-scale (300mm) integrated photonics. In that ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  10. OSD232-D04: Gravity Gradiometer Demonstration on an Inertial Platform

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Quantum Science OBJECTIVE: This project will demonstrate the operation of a single-axis gravity gradiometer with a noise floor below at approximately 10 Eotvos (or similar performance if already demonstrated) on a moving platform in environments where vibrations, accelerations, rotations, and temperature swings cannot be neglected. DESCRIPTION: Atomic grav ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
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