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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-GM-22-001: IDeA Regional Entrepreneurship Development (I-RED) Program (STTR) (UT2 Clinical Trial Not Allowed)

    Release Date: 10-07-2021Open Date: 12-05-2021Due Date: 01-05-2022Close Date: 01-06-2022

    Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, also known as America’s seed fund, support US-owned and operated small businesses to engage in federal research and development that has a strong potential for commercialization. NIH’s SBIR and STTR programs invest over 1.2 billion dollars into health and life science companies tha ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-21-297: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R43/R44 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK) ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-21-298: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R41/R42 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    Purpose The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokin ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. OSD213-008: Aim Augmentation for Small Caliber Weapons Systems

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  5. OSD213-009: Versatile Warhead for Low-velocity 40mm Wall-penetrating Munition

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  6. SCO213-001: Novel Spacecraft Power Supply

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: Develop alternative power sources for spacecraft to provide operational or design improvements over traditional solar power systems. DESCRIPTION: The DoD is seeking functional alternative power source options to enable novel spacecraft designs and payload operations. The power source must be scalable to support ESPA-class spacecraft variants (1/4, 1/2, full ESPA, ESPA-Grande) and must ...

    SBIRPhase I/Phase IIDepartment of DefenseStrategic Capabilities Office
  7. SCO8213-002: Midpoint and tactical data aggregation to enable cyber operations

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseStrategic Capabilities Office
  8. SCO213-003: High Throughput Photonic Processor for AI/ML programs

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: The objective of this photonic processor is to address the need of a high throughput AI/ML processor that can address full sensor resolution output without the need for pre-filtering potential throughput of 480 frames per sec or 88k targets filtered and identified in 3 minutes. A one-step over a two-step inference process. All this capability could fit into a 1 or 1.5U rack system. T ...

    SBIRPhase I/Phase IIDepartment of DefenseStrategic Capabilities Office
  9. OSD21C-001: Solid State Non-Reciprocal Microwave Devices

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    STTRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  10. OSD21C-002: Magnetic-free non-reciprocal and topological integrated microwave components

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: Design, fabricate, and demonstrate a new category of subwavelength non-reciprocal circulators, including arrays of them to form photonic topological insulators, operating at microwave frequencies without the need of magnetic materials and/or magnetic bias, which are compatible with integrated circuits technology. In contrast to conventional magnetic-based non-reciprocal components, the ...

    STTRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
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