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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-CA-22-017: Small Business Transition Grant For Early Career Scientists (R42 Clinical Trial Not Allowed)

    Release Date: 03-21-2022Open Date: 07-22-2022Due Date: 08-22-2022Close Date: 08-23-2022

    Purpose Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), and National Institute on Drug Abuse (NIDA) intend to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technology from academic laboratories into small bu ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. OSD22B-001: Scalable Production of Engineered Designer Proteins Containing Multiple Distinct Non-canonical Amino Acids

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Biotechnology TECHNOLOGY AREA(S): Materials OBJECTIVE: Develop cellular or cell-free synthetic processes from genomically recoded organisms to achieve robust, reliable and cost-effective production of engineered proteins containing multiple distinct non-canonical amino acids that are scalable to manufacturing-relevant levels. DESCRIPTION: Biological s ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  3. OSD22B-002: Intelligent Multi-Laser System for Metal Additive Manufacturing

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Materials; Information Systems OBJECTIVE: To significantly accelerate the laser metal powder bed additive manufacturing (LPBAM) process and improve the microstructural quality of LPBAM parts by developing a scalable, intelligent multi-laser based system. In this AM system, some of the lasers q ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  4. OSD22B-003: Monolithic CMOS Integration of SiGeSn High Performance Optoelectronic Devices

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics; Network Command, Control and Communications; General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Sensors; Electronics; Chem Bio Defense; Space Platforms; Materials; Information Systems OBJECTIVE: Develop a SiGeSn monolithic integration technology with CMOS for optoelectronic devices operating in the wavelength range between 2.0 an ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  5. OSD22B-004: Ultra-Pure Atomic Wafer Fusion for Ultra-Wide Bandgap, Ultra-High Power, High Thermal Conductivity Power Switches

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics; Network Command, Control and Communications; General Warfighting Requirements TECHNOLOGY AREA(S): Ground Sea; Electronics; Materials OBJECTIVE: Develop a high purity, ultra-high vacuum surface activated bonded wafer fusion (UHV-SAB) tool for heterogeneous integration of dissimilar materials for electronic materials integration and therma ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  6. PAR-22-102: Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (U43/U44 Clinical Trial Optional)

    Release Date: 01-21-2022Open Date: 02-28-2022 Due Dates: Multiple Close Date: 12-05-2024

    Background Currently, there are only three medications (four formulations) approved by the FDA for the treatment of alcohol use disorder (AUD). The need for additional medications to treat those affected by AUD is urgently needed.In addition,alcohol misuseaffects virtually all tissues and is linked with dysfunction and failure of many organs and systems including the liver, heart, pancreas, lung, ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PAR-21-298: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R41/R42 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    Purpose The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokin ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-21-267: NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)

    Release Date: 07-16-2021Open Date: 08-07-2021 Due Dates: Multiple Close Date: 04-06-2024

    Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treatm ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-21-226: Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed)

    Release Date: 04-30-2021Open Date: 08-05-2021 Due Dates: Multiple Close Date: 09-06-2024

    Many NIH-funded research projects rely on vertebrate and invertebrate animal models to study the basics of biology and physiology, to investigate pathological conditions, to examine disease mechanisms and treatments, and to design novel therapies and translational procedures. In this regard, ORIP plays a vital role through its support of research infrastructures and animal models of human diseases ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-20-239 : Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (STTR) (R41/R42 Clinical Trial Not Allowed)

    Release Date: 06-25-2020Open Date: 08-04-2020 Due Dates: Multiple Close Date: 09-03-2022

    The primary educational objective of this FOA is to provide opportunities for eligible SBCs to submit NIH STTR grant applications to develop IDM STEM products that address student career choice and health and medicine topics for: (1) pre-kindergarten to grade 12 (P-12) students and teachers or (2) informal science education (ISE) audiences. The second educational objective is to inform the America ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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