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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-NS-22-033: Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection- Interventions from Small Businesses (U44 Clinical Trial Not Allowed)

    Release Date: 01-06-2022Open Date: 02-14-2022Due Date: 03-14-2022Close Date: 03-15-2022

    Purpose The purpose of this funding opportunity announcement (FOA) is to solicit applications for cerebroprotective intervention research projects from eligible U.S. small businesses to be tested in the NINDS Stroke Preclinical Assessment Network (SPAN).SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent mode ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-MD-22-004: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 01-05-2022Open Date: 03-05-2022Due Date: 04-04-2022Close Date: 04-05-2022

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-MD-22-003: Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)

    Release Date: 01-05-2022Open Date: 03-04-2022Due Date: 04-04-2022Close Date: 04-05-2022

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. OSD221-006: Stand-alone multi-axis compact portable quantum accelerometer

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Quantum Science TECHNOLOGY AREA(S): Sensors, Electronics and Electronic Warfare OBJECTIVE: Build a compact portable 3-axis quantum-based accelerometer and demonstrate on a moving platform. DESCRIPTION: A significant portion of quantum IMU development has focused on single-axis inertial sensors. Of these, the majority have been gyroscopes and gravimete ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  5. OSD221-007: High yield atomic vapor cell manufacturing and packaging for atomic clocks and magnetometers

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Quantum Science TECHNOLOGY AREA(S): Sensors, Electronics and Electronic Warfare; Materials / Processes OBJECTIVE: Develop a manufacturing process which allows greater yield (>80%) per wafer batch on vapor cell wafer runs to support quantum clocks and magnetometers. DESCRIPTION: Over the last decade, quantum sensor technology (including atomic clocks a ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  6. OSD221-D05: Networked quantum sensor for geolocation of anomalous underground ferrous sources

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Quantum Science TECHNOLOGY AREA(S): Sensors, Electronics and Electronic Warfare OBJECTIVE: Detect and geo-locate subterranean tunneling activities by using a quantum networked magnetometer. DESCRIPTION: In challenging environments, the DoD needs the capability to distinguish hidden threats in subsurface environments. These threats manifest as hidden, ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  7. OSD221-D08: Open environment nuclear quadrupole magnetic resonance detection

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Quantum Science TECHNOLOGY AREA(S): Sensors, Electronics and Electronic Warfare OBJECTIVE: Develop a quantum magnetometer that is widely tunable between 100 Hz and 10 MHz to detect and distinguish RF signals with sensitivity near 1 fT/Hz1/2. The sensor system should simple and easily adapted to any system that uses an antenna in this frequency range. The ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  8. RFA-HL-23-008: NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

    Release Date: 11-16-2021Open Date: 01-28-2022 Due Dates: Multiple Close Date: 02-29-2024

    Since its inception in 1982, the NIH SBIR program has provided the small business community with seed funding to support the development of a broad array of commercial products to detect, diagnose, treat, and prevent disease.? It provides an important funding mechanism for bringing new interventions to patients and clinicians. The SBIR program is structured in three phases. The objective in Phase ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. RFA-HL-23-009: NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

    Release Date: 11-16-2021Open Date: 01-28-2022 Due Dates: Multiple Close Date: 02-29-2024

    Since its inception in 1982, the NIH SBIR program has provided the small business community with seed funding to support the development of a broad array of commercial products to detect, diagnose, treat, and prevent disease. It provides an important funding mechanism for bringing new interventions to patients and clinicians. The SBIR program is structured in three phases. The objective in Phase I ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-21-297: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R43/R44 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK) ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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