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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. DHA221-001: Prolonged Care: To Demonstrate a Medicated Combat Tourniquet Capable of Wound Infection Treatment Delivery

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Bio Medical OBJECTIVE: To reimagine the current fielded tourniquet beyond prevention of exsanguination and demonstrate next generation designs capable of delivering treatment for the prevention of infection in a prolonged care setting. The technology must retain or improve upon the original functi ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  2. DHA221-002: Scalable Multi-person Hearing Protection Device Fit-testing System

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Bio Medical OBJECTIVE: Develop a system that can simultaneously fit-test multiple people with hearing protection devices (HPDs). The system should be usable in clinical and non-clinical settings to quickly test the fit of HPDs from various manufacturers. DESCRIPTION: The Hearing Conservation P ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  3. DHA221-003: Olfactory Neuroepithelium Functional Diagnostic Tool

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Bio Medical OBJECTIVE: To develop a non-invasive diagnostic device that can be used to determine the cellular and functional characteristics of olfactory neuroepithelium with limited or no anesthesia. The device should be able to determine thickness of mucus on top of the mucosa and then be able c ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  4. DHA221-004: Blind 3D Kinematic Measurement of High-Rate Complex Surface Deformation

    Release Date: 12-01-2021Open Date: 01-12-2022Due Date: 02-10-2022Close Date: 02-10-2022

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Bio Medical OBJECTIVE: Develop and demonstrate technologies capable of measuring complex surface response kinematics at the interface between the torso and body armor system. DESCRIPTION: Body armor systems can be comprised of hard and soft materials which are designed to prevent ballistic pro ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  5. RFA-DA-22-018: Advancing Validated Drug Targets for Substance Use Disorders (R41/R42- Clinical Trial Not Allowed)

    Release Date: 07-29-2021Open Date: 01-18-2022Due Date: 02-18-2022Close Date: 02-19-2022

    Background Substance use disorders (SUDs) affect people from all walks of life and all age groups. These illnesses are common, recurrent, and often serious, but they are treatable, and many people recover. SUDs occur when the recurrent use of drugs cause clinically significant impairment, including health problems, disability, and failure to meet major responsibilities at work, school, or home. T ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-DA-22-023: Advancing Validated Drug Targets for Substance Use Disorders (R43/R44- Clinical Trial Not Allowed)

    Release Date: 07-29-2021Open Date: 01-18-2022Due Date: 02-18-2022Close Date: 02-19-2022

    Background Substance use disorders (SUDs) affect people from all walks of life and all age groups. These illnesses are common, recurrent, and often serious, but they are treatable, and many people recover. SUDs occur when the recurrent use of drugs causes clinically significant impairment, including health problems, disability, and failure to meet major responsibilities at work, school, or home. ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-NS-22-033: Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection- Interventions from Small Businesses (U44 Clinical Trial Not Allowed)

    Release Date: 01-06-2022Open Date: 02-14-2022Due Date: 03-14-2022Close Date: 03-15-2022

    Purpose The purpose of this funding opportunity announcement (FOA) is to solicit applications for cerebroprotective intervention research projects from eligible U.S. small businesses to be tested in the NINDS Stroke Preclinical Assessment Network (SPAN).SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent mode ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. RFA-MD-22-004: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 01-05-2022Open Date: 03-05-2022Due Date: 04-04-2022Close Date: 04-05-2022

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. RFA-MD-22-003: Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)

    Release Date: 01-05-2022Open Date: 03-04-2022Due Date: 04-04-2022Close Date: 04-05-2022

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-20-130: SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1 Clinical Trial Required)

    Release Date: 07-10-2020Open Date: 08-08-2020 Due Dates: Multiple Close Date: 04-06-2022

    Purpose The NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies that benefit society. The main objective in SBIR/STTR Phase I is to establish the technical merit and feasibility of the proposed research and development ( ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
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