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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. ARMY SBIR 2021.4: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    This topic is released under a DoD Component Annual BAA. Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://rt.cto.mil/rtl-small-business-resources/sbir-sttr/ for specific topic open and close dates as well as BAA documents and instructions.”

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  2. DARPA BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 12-17-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    This topic is released under a DoD Component Annual BAA. Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://rt.cto.mil/rtl-small-business-resources/sbir-sttr/ for specific topic open and close dates as well as BAA documents and instructions.”

    SBIRPhase I/Phase IIDepartment of DefenseDefense Advanced Research Projects Agency
  3. SDA BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    This topic is released under a DoD Component Annual BAA. Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://rt.cto.mil/rtl-small-business-resources/sbir-sttr/ for specific topic open and close dates as well as BAA documents and instructions.”

    SBIRPhase IDepartment of DefenseSpace Development Agency
  4. NIH/NCI 438: UNDERSTANDING CANCER TUMOR GENOMIC RESULTS: TECHNOLOGY APPLICATIONS FOR COMMUNITY PROVIDERS

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Fast-Track proposals will NOT be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 2-3 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary Next-generation sequencing (NGS)–based technology has l ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. NIH/NCI 434: ULTRA-FAST DOSE RATE (FLASH) RADIATION DETECTORS AND SAFETY SYSTEMS

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Number of anticipated awards: 2-3 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Page 74 Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary An important development in the field of radiation oncolo ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-NS-21-022: Translational Neural Devices (U44 Clinical Trial Optional)

    Release Date: 04-28-2021Open Date: 06-01-2021 Due Dates: Multiple Close Date: 02-21-2024

    A. Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical saf ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-HG-21-008: Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44 Clinical Trial not Allowed)

    Release Date: 03-30-2021Open Date: 05-26-2021 Due Dates: Multiple Close Date: 02-02-2023

    Purpose This Funding Opportunity Announcement (FOA) solicits R43/R44 grant applications to innovate and develop the early commercial stages of novel technologies that will enable greater than a one order of magnitude improvement in DNA sequencing, or methods for direct sequencing of the diversity of entire RNA molecules. Advances in genomics and more broadly in biomedical research have been great ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. NIH/NIA 006: The Development of Mechanism-based Adult Stem Cell Treatments to Combat Aging Pathologies

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Fast- Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 1 to 2 Budget (total costs, per award): Phase I: $350,000 for 12 months; Phase II: $2,000,000 for 2 years It is strongly suggested that proposals adhere to the above budget amounts and project periods. Proposals with budgets exceeding the above amounts and project periods may no ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-21-247: Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial Not Allowed)

    Release Date: 07-09-2021Open Date: 10-01-2021 Due Dates: Multiple Close Date: 06-16-2023

    Purpose This Funding Opportunity Announcement (FOA) solicits R43/R44 grant applications to accelerate innovation and early development in the emerging field of single-molecule protein sequencing (SMPS). This FOA is seeking novel technologies or significant improvements to existing technologies. Exploration of technologies other than those currently being commercialized is highly encouraged. The s ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. NIH/NCATS 022: Technological Development and Validation of Remote Measures for Use in Clinical Trials in Individuals with Rare Diseases

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    (Fast-Track proposals will not be accepted. Phase II information is provided only for informational purposes to assist Phase I offerors with their long-term strategic planning.) Number of anticipated awards: 1 to 4 Budget (total costs, per award): Phase I: $325,000 for 9 months; Phase II: $2,000,000 for 2 years It is strongly suggested that proposals adhere to the above budget amounts and project ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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