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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. A214-014: Advanced GPS-Based Minefield Detection/Clearance System

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    A214-014 ARMY SBIR 2021.4 Department of Defense ...

    SBIRPhase I/Phase IIDepartment of Defense
  2. HQ085021S0001-03: Advanced Space Mesh Networking

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    HQ085021S0001-03 SDA SBIR HQ085021S0001 Department of Defense ...

    SBIRPhase IDepartment of Defense
  3. A214-033: Advanced Thermal Management Systems

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    A214-033 ARMY SBIR 2021.4 Department of Defense ...

    SBIRPhase I/Phase IIDepartment of Defense
  4. PA-19-022: Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R43/R44 Clinical Trial Not Allowed)

    Release Date: 10-10-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Purpose Digital dentistry uses advanced materials and powerful manufacturing technologies aided by 3D imaging and processing software algorithms to produce dental devices and perform complex dental procedures. This Funding Opportunity Announcement (FOA) encourages innovation, optimization and customization of core technologies in digital dentistry that improve efficiency of oral healthcare delive ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAS-19-316 : Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

    Release Date: 07-18-2019Open Date: 12-05-2019 Due Dates: Multiple Close Date: 09-05-2022

    Recent recommendations and milestones for AD/ADRD research from the National Alzheimer’s Project Act, the 2015 Alzheimer’s Disease Research Summit, the 2018 Alzheimer’s Disease Research Summit, and the 2019 Alzheimer’s Disease and Related Dementias Research Summit present a wide range of research and development proposals which, if pursued, can reduce the human burden and healthcare costs ...

    SBIRPhase I/Phase IIDepartment of Health and Human Services
  6. PAR-21-057: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 11-19-2020Open Date: 01-22-2021 Due Dates: Multiple Close Date: 09-08-2023

    Background A biomarker is a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints, as well as composite biomarkers or biomarker signatures. Becaus ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-TR-21-010: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 01-13-2021Open Date: 03-13-2021 Due Dates: Multiple Close Date: 01-13-2022

    A. Overview While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underly multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecu ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. A214-013: Behavioristic Electromagnetic Spectrum Assessment General Learning Engine (BEAGLE)

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    A214-013 ARMY SBIR 2021.4 Department of Defense ...

    SBIRPhase I/Phase IIDepartment of Defense
  9. RFA-HD-22-018: Biomarker Research to Support Fertility Regulation Development by Small Business (R43 Clinical Trial Optional)

    Release Date: 04-15-2021Open Date: 06-29-2021Due Date: 07-29-2021Close Date: 07-30-2021

    Purpose The purpose of this Funding Opportunity Announcement (FOA) is to invite SBIR applications to support and facilitate the development of new and/or improved clinical biomarkers and companion biomarker diagnostics (e.g., point of care and/or direct-to-consumer tests, DTC) to support the clinical development of non-hormonal contraceptive product(s) for men and women. Background Nearly half ...

    SBIRPhase IDepartment of Health and Human ServicesNational Institutes of Health
  10. A214-019: Biometric Data Cleansing

    Release Date: 12-02-2020Open Date: 01-01-2021Due Date: 12-31-2021Close Date: 12-31-2021

    A214-019 ARMY SBIR 2021.4 Department of Defense ...

    SBIRPhase I/Phase IIDepartment of Defense
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