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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. HHS-2021-ACL-NIDILRR-BISA-0033: National Institute on Disability, Independent Living and Rehabilitation Research

    Release Date: 12-04-2020Open Date: 12-04-2020Due Date: 02-02-2021Close Date: 02-02-2021

    The Administrator of the Administration for Community Living invites applications for new awards for NIDILRR's Fiscal year 2021 Small Business Innovation Research (SBIR) Program (CFDA 93.433). All SBIR projects funded by NIDILRR must address the needs of individuals with disabilities (see 29 U.S.C. 760). The scientific and technical merit of the proposed research/research and development (R/R&D) i ...

    SBIRPhase IDepartment of Health and Human ServicesAdministration for Community Living
  2. RFA-NS-19-017: HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)

    Release Date: 12-10-2018Open Date: 12-10-2018 Due Dates: Multiple Close Date: 02-22-2021

    Purpose: The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational activities and clinical trials to treat pain with innovative, targeted, and non-addictive diagnostic and/or therapeutic devices that improve patient outcomes and decrease or eliminate the need to prescribe opioids. Activities supported in this program include ...

    SBIRPhase I/Phase IIDepartment of Health and Human Services
  3. PA-18-705 : SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed)

    Release Date: 03-06-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    The SBIR Technology Transfer (SBIR-TT) Funding Opportunity Announcement (FOA) is intended to help move commercially-viable technologies from the NIH Intramural Program to the marketplace. Small Business Concerns (SBCs) are encouraged to submit applications that further develop available technologies from the NIH Intramural Program and bring them to the commercial market. While universities can spi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PA-18-786 : Wearable Alcohol Biosensors (SBIR) (R43/R44- Clinical Trial Optional)

    Release Date: 05-15-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    Rapid advances are being made in wearable technology, including clothing, jewelry and other devices with broadly diverse functions that meet medical or consumer needs. This FOA seeks applications from small businesses that propose to design and produce a non-invasive wearable device to monitor blood alcohol levels in real time. Alcohol detection technology for personal alcohol monitoring has b ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PA-18-785 : Wearable Alcohol Biosensors (STTR) (R41/R42- Clinical Trial Optional)

    Release Date: 05-15-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    Rapid advances are being made in wearable technology, including clothing, jewelry and other devices with broadly diverse functions that meet medical or consumer needs. This FOA seeks applications from small businesses that propose to design and produce a non-invasive wearable device to monitor blood alcohol levels in real time. Alcohol detection technology for personal alcohol monitoring has b ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PA-18-816 : Better Defining Growth Medium to Improve Reproducibility of Cell Culture (STTR) (R41/R42- Clinical Trial Not Allowed)

    Release Date: 06-05-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    Fetal bovine serum (FBS) is the most widely used growth supplement for cell culture; it cost-effectively supports the survival, growth, and differentiation of many cell lines by providing nutrients, growth signals, and protection from stress. Although serum is an effective growth promoter, it is variable in its composition, activity, and effects on cellular phenotypes. This variability introduces ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PA-18-815 : Better Defining Growth Medium to Improve Reproducibility of Cell Culture (SBIR) (R43/R44- Clinical Trial Not Allowed)

    Release Date: 06-05-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    Fetal bovine serum (FBS) is the most widely used growth supplement for cell culture; it cost-effectively supports the survival, growth, and differentiation of many cell lines by providing nutrients, growth signals, and protection from stress. Although serum is an effective growth promoter, it is variable in its composition, activity, and effects on cellular phenotypes. This variability introduces ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-19-266 : Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed)

    Release Date: 05-02-2019Open Date: 08-05-2019 Due Dates: Multiple Close Date: 04-05-2021

    Many NIH-funded research projects rely on vertebrate and invertebrate animals to study basics of biology and physiology, to investigate pathological conditions, to build models of human diseases, and to design novel therapies and translational procedures. ORIP plays a vital role in the area of NIH-funded animal model research by supporting specialized animal research facilities and the development ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-19-265 : Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R43/R44 Clinical Trial Not Allowed)

    Release Date: 05-02-2019Open Date: 08-05-2019 Due Dates: Multiple Close Date: 04-05-2021

    Many NIH-funded research projects rely on vertebrate and invertebrate animals to study basics of biology and physiology, to investigate pathological conditions, to build models of human disease pathways, and to design novel therapies and translational procedures. ORIP plays a vital role in the area of NIH-funded animal model research by supporting specialized animal research facilities and the dev ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PA-20-265 : PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

    Release Date: 07-14-2020Open Date: 08-05-2020 Due Dates: Multiple Close Date: 04-06-2021

    Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, also known as America's Seed Fund, are one of the largest sources of early-stage capital for technology commercialization in the United States. These programs enable US-owned and operated small businesses to conduct research and development that has a strong potential for commercializa ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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