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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DA-24-018: Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R43/R44 Clinical Trial Optional)

    Release Date: 05-24-2023Open Date: 10-09-2023Due Date: 11-10-2023Close Date: 11-11-2023

    In 2020, 40.3 million people aged 12 or older had substance use disorder (SUD) in the past year. Of those, 2.6 million people (6.4%) received any in-person treatment, while 2.2 million (5.4%) received virtual services for substance use treatment. Therefore, an estimated 35 million people did not receive any treatment. To receive treatment, individuals need to receive a diagnosis from a provider, ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-CA-23-034: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 04-21-2023Open Date: 07-21-2023Due Date: 08-21-2023Close Date: 08-22-2023

    Purpose The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medic ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-CA-23-035: Small Business Transition Grant For Early Career Scientists (R42 Clinical Trial Not Allowed)

    Release Date: 04-21-2023Open Date: 07-21-2023Due Date: 08-21-2023Close Date: 08-22-2023

    Purpose Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), and National Institute on Drug Abuse (NIDA) intend to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technology from academic laboratories into small busin ...

    SBIR/STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. DTRA232-001: Computational Modeling of Human Blast Injuries in the Battle Fields

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Combat Casulty care; Biotechnology The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, wh ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  5. DTRA232-002: Real-time Criticality Detection System for Field Operations

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Nuclear; Integrated Sensing and Cyber; Emerging Threat Requirements OBJECTIVE: The Defense Threat Reduction Agency (DTRA) seeks technologies that can provide Department of Defense (DoD) personnel with the ability to pre-emptively identify and react to situations with potential nuclear criticality concerns. Events involving nuclear reactors or associated fa ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  6. DTRA232-003: ATAK Secure Routing Solution for CBRN Operations

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Network Systems-of-Systems OBJECTIVE: DTRA seeks the development of a compact, ruggedized, all-in-one network routing solution for tactical use of the CBRN Plug-In within a local Android Team Awareness Kit (ATAK) Server that is compatible with the existing MANET radios currently employed by OI-CO and SOCOM. For DTRA, this will enable Technical Su ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  7. DTRA232-004: A Portable Hardware Solution for Real-Time DNA and RNA Sequencing

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Biotechnology The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  8. DTRA232-005: Field Calibration of Standoff, Ground-Based Hyperspectral Imaging Sensors Used for Vapor Mass Quantification of Plumes

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): General Warfighting Requirements (GWR); Emerging Threat Requirements The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulati ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  9. DTRA232-006: Standoff Aerosol Plume Density and Particle Size Quantification

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): General Warfighting Requirements (GWR); Emerging Threat Reduction OBJECTIVE: The objective of this effort is to develop, calibrate, verify and validate a standoff ground-based optical system capable of measuring aerosol plume density and particle size distribution. DESCRIPTION: In order to quantify the inadvertent release of hazardous material associated w ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Threat Reduction Agency
  10. PAR-23-267: Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

    Release Date: 04-18-2023Open Date: 05-06-2023 Due Dates: Multiple Close Date: 06-07-2025

    Purpose This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support SBCs to propose the development of novel extracellular vesicle-based therape ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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