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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-TR-22-032: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44- Clinical Trail Not Allowed)

    Release Date: 09-19-2022Open Date: 10-21-2022 Due Dates: Multiple Close Date: 08-22-2023

    Section I. Funding Opportunity Description This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR)Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-NS-23-006: HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)

    Release Date: 09-15-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 04-05-2025

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-DE-23-008: Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (Fast-Track- R44- Clinical Trial Not Allowed)

    Release Date: 08-02-2022Open Date: 10-10-2022Due Date: 11-09-2022Close Date: 11-10-2022

    Purpose This FOA seeks to accelerate the clinical translation of novel biomaterials for DOC applications through implementation of advanced data-driven tools specifically designed to overcome critical bottlenecks in R&D cycles that lead to delays in regulatory evaluations and translation to human use. This initiative leverages the FDA-CDRH’s Medical Device Development Tools (MDDT) program frame ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. 8.1: Forests and Related Resources

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The Forests and Related Resources topic area aims to address the health, diversity and productivity of the Nation’s forests and grasslands to meet the needs of present and future generations through the development of environmentally sound approaches to increase productivity of forest lands, improve sustainability of forest resources, and develop value-added materials derived from woody resource ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  5. 8.2: Plant Production and Protection (Biology)

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The objective of this topic area is to examine novel ways of enhancing crop production and protection by applying biological approaches to develop new methods for plant improvement and pest management; apply traditional plant breeding methods and/or new technologies to develop new food and non-food crop plants, develop diagnostic technologies for plant diseases; develop plant characteristics that ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  6. 8.3: Animal Production and Protection

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    Protein and other nutrients from animal sources are an important component of diets worldwide. Agricultural animals also provide skins, fiber, feathers and other products with economic importance. There is a growing need for these products as the global population expands and demand becomes higher also due to more disposable income for hundreds of millions of people. Fulfilling this need will requ ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  7. 8.4: Conservation of Natural Resources

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The goal of the program is to commercialize innovative technologies that are developed with the purpose to conserve, monitor, improve and/or protect the quality and/or quantity of natural resources and reduce potential waste streams while sustaining climate-smart, optimal farm and forest productivity and profitability. The objective of this topic area is the conservation of soil, water, air, and o ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  8. 8.5: Food Science and Nutrition

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The Food Science and Nutrition topic area aims to fund projects that support research focusing on developing new and improved processes, technologies, products, or services that address emerging food safety, food processing and nutrition issues. The program will fund projects to: 1) increase the understanding of the physical, chemical, and biological properties of food; 2) improve methods for the ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  9. 8.6: Rural and Community Development

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The objective of this topic area is to improve the quality of life in rural America by creating and commercializing technologies that address important economic and social development issues or challenges in rural America. Projects must explicitly discuss the specific rural problem or opportunity that will be examined and how the proposed science-based technology will successfully address the prob ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
  10. 8.7: Aquaculture

    Release Date: 07-25-2022Open Date: 07-25-2022Due Date: 10-25-2022Close Date: 10-25-2022

    The Aquaculture topic area funds research projects with the overall goal of leading to improved production efficiency and increased competitiveness of private sector, commercial aquaculture in the United States. This topic area aims to develop new technologies that will enhance the knowledge and technology base necessary for the expansion of the domestic aquaculture industry. Seafood production fr ...

    SBIR/STTRPhase IDepartment of AgricultureNational Institute of Food and Agriculture
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