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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-18-578: Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (U44- Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 02-27-2018 Due Dates: Multiple Close Date: 12-04-2020

    Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by support ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-HD-21-020 : Non-invasive Diagnostics to Improve Gynecologic Health (R43/R44 Clinical Trial Optional)

    Release Date: 07-02-2020Open Date: 11-10-2020Due Date: 12-10-2020Close Date: 12-11-2020

    Purpose The purpose of the Non-invasive Diagnostics in Gynecologic Health RFA is to support SBIR projects to small businesses using advanced technologies (e.g., bio-chips, microfluidics, and mobile technologies) to develop novel or improved diagnostic and/or screening approaches, tools, or devices for endometriosis, adenomyosis, and/or uterine fibroids. The ultimate goal of the program is to imp ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-18-303: Innovative Molecular Analysis Technology Development for Cancer Research and Clinical Care (R43/R44 Clinical Trial Not Allowed)

    Release Date: 10-03-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) proposing research for commercial development of novel cancer-relevant technologies. The proposed research projects are expected to focus on the development of highly-innovative technologies that improve molecular and/or cellular analysis of cancer ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PAR-18-512 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The Small Business Innovation Research (SBIR) program is a highly competitive program that encourages domestic small businesses to engage in Federal Research/Research and Development (R/R&D) that has the potential for commercialization. Through a competitive awards-based program, SBIR enables small businesses to explore their technological potential and provides the incentive to profit from its c ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PA-18-525 : Radiological/Nuclear Medical Countermeasure Product Development Program (SBIR) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-19-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) grant applications focused on specific product development activities for radiological/nuclear medical countermeasures leading to Investigational New Drug (IND) or Investigational Device Exemption (IDE) submission packages to the U.S. Food and Drug Administration (FDA). T ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-18-565 : Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44- Clinical Trial Optional)

    Release Date: 01-09-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The NIH and other research sponsors invest a significant amount of funds in the development of new technologies to study the brain and behavior, from basic and clinical perspectives, through a variety of mechanisms, including, from NIH, the R01, R21, R33, P01, P41, and P50 grants. This investment has produced a large number of technologies that include hardware (e.g., instruments, devices, etc.), ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PAR-18-512 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Section I. Funding Opportunity Description The Small Business Innovation Research (SBIR) program is a highly competitive program that encourages domestic small businesses to engage in Federal Research/Research and Development (R/R&D) that has the potential for commercialization. Through a competitive awards-based program, SBIR enables small businesses to explore their technological potential a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-18-565 : Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44- Clinical Trial Optional)

    Release Date: 01-09-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The NIH and other research sponsors invest a significant amount of funds in the development of new technologies to study the brain and behavior, from basic and clinical perspectives, through a variety of mechanisms, including, from NIH, the R01, R21, R33, P01, P41, and P50 grants. This investment has produced a large number of technologies that include hardware (e.g., instruments, devices, etc.), ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PA-18-567 : Competing Renewal Awards of SBIR Phase IIB Grants for Brain and Behavior Tools (R44-Clinical Trial Optional)

    Release Date: 01-09-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    There are important technologies within the biomedical and biobehavioral space that do not require federal regulatory approvals as part of the technology development efforts, but that still require extraordinary time and effort to develop. The purpose of this FOA is to encourage applications for renewals of existing Phase II grants which are supporting research and development of such technologies ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PA-18-566 : Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43/R44 Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Background The overarching goal of the Small Business Innovation Research (SBIR) program at the National Institute of Mental Health (NIMH) is to support small businesses to develop technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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