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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. HHS-2021-ACL-NIDILRR-BISB-0026: Small Business Innovation Research Program (SBIR) Phase II Department of Health and Human Services Administration for Community Living

    Release Date: 03-30-2021Open Date: 03-30-2021Due Date: 06-01-2021Close Date: 06-01-2021

    SBIR Phase I grantees who successfully completed their Phase I grant in fiscal year 2019, 2020 or 2021 are eligible to apply. These eligible applicants only include (1) Phase I grantees who successfully completed their Phase I work within the past 3 years (2019, 2020, 2021) with Phase I funding from NIDILRR, or (2) Phase I grantees who successfully completed with Phase I work within the past 3 yea ...

    SBIRPhase IIDepartment of Health and Human ServicesAdministration for Community Living
  2. RFA-CA-21-036: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 03-25-2021Open Date: 07-06-2021Due Date: 08-06-2021Close Date: 08-07-2021

    Purpose The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-MD-21-006: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 03-11-2021Open Date: 04-05-2021Due Date: 05-03-2021Close Date: 05-04-2021

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-MD-21-005: Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)

    Release Date: 03-11-2021Open Date: 04-05-2021Due Date: 05-03-2021Close Date: 05-04-2021

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancements, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other populations who experience ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-21-114: NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed)

    Release Date: 01-25-2021Open Date: 03-05-2021 Due Dates: Multiple Close Date: 01-06-2024

    Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treat ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-21-082: NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

    Release Date: 01-14-2021Open Date: 04-14-2021 Due Dates: Multiple Close Date: 01-15-2024

    Purpose This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials, including mechanistic studies associated with clinical trials. A clinical trial is defined by NIH as: "A research study in which one or more human subjects are prospectivel ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-TR-21-010: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 01-13-2021Open Date: 03-13-2021 Due Dates: Multiple Close Date: 01-13-2022

    A. Overview While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underly multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecu ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. 8.1: Forests and Related Resources

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Forests and Related Resources topic area aims to address the health, diversity, and productivity of the Nation’s forests to meet the needs of present and future generations through the development of environmentally sound approaches to increase productivity of forest lands, improve sustainability and develop value-added materials derived from forest resources.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  9. 8.2: Plant Production and Protection- Biology

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The objective of this topic area is to examine novel ways of enhancing crop production and protection by: applying biological approaches to develop new methods for plant improvement, applying traditional plant breeding methods and new technologies to develop new food and non- food crop plants, developing plant characteristics that reduce the harmful impact of plant pests and biotic stresses, and d ...

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  10. 8.3: Animal Production and Protection

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Animal Production and Protection topic area aims to develop innovative, marketable technologies that will provide significant benefit to the production and protection of agricultural animals.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
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