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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DA-25-054: Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R43/R44 Clinical Trials Not Allowed)

    Release Date: 01-29-2024Open Date: 06-25-2024Due Date: 07-25-2024Close Date: 07-26-2024

    Background: Drug discovery and development is a high-cost, high-risk, and time-consuming endeavor where the failure rate of therapeutic candidates that enter clinical trials is 90%. Because of this, in recent years, artificial intelligence (AI), including machine learning ( ML) technologies, has been embraced to reduce clinical failure rates and to speed up drug discovery. AI/ML technologies are ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-24-099: NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

    Release Date: 01-29-2024Open Date: 04-12-2024 Due Dates: Multiple Close Date: 01-14-2027

    Purpose This Notice of Funding Opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials, including mechanistic studies associated with clinical trials. This program provides support for milestone-driven, hypothesis-driven clinical trials related to the research mi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. A224-014: Helicopter Expedited Refueling Operations (HERO)

    Release Date: 10-03-2023Open Date: 03-12-2024Due Date: 03-31-2025Close Date: 04-01-2024

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120 – 130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730 â ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  4. A244-P017: xTechScalable AI 2

    Release Date: 10-03-2023Open Date: 03-11-2024Due Date: 03-31-2025Close Date: 11-18-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Artificial Intelligence/ Machine Learning; Trusted AI and Autonomy; Advanced Computing and Software; Human-Machine Interfaces OBJECTIVE: Topic 1: Scalable Tools for Automated AI Risk Management and Algorithmic Analysis As the Army deploys Artificial Intelligence (AI) systems, there is an inherent risk that the AI model could fail to perform as expe ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  5. 24.2-CSAI-1: Complete Streets AI Initiative: Generating, Integrating, and Activating Data for Mobility

    Release Date: 03-11-2024Open Date: 03-11-2024Due Date: 05-10-2024Close Date: 05-10-2024

    24.2-CSAI-1 FY24.2 DOT SBIR Solicitation Department of Transportation ...

    SBIRPhase IDepartment of Transportation
  6. A244-018: Tactical Implementation of Quantum Hardening

    Release Date: 10-03-2023Open Date: 03-05-2024Due Date: 03-31-2025Close Date: 04-23-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Quantum Science; Advanced Computing and Software; Integrated Network System of Systems The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120 – 130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Expor ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  7. RFA-AA-24-001: High-Throughput Screening (HTS) Platform for Discovery of Medications to Treat Alcohol Use Disorder (R43/R44 Clinical Trials Not Allowed)

    Release Date: 12-21-2023Open Date: 03-05-2024Due Date: 04-09-2024Close Date: 04-10-2024

    Drug development is challenging, particularly for Central Nervous System (CNS) medications. It takes approximately 18 years to move a potential CNS medication from its initial discovery phase to the marketplace, often costing several billion dollars. The failure rate is high (only 8% of new CNS compounds entering Phase I studies will reach the market) and contributes to the high costs and slow rat ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-24-158: https://grants.nih.gov/grants/guide/PA-files/PAR-24-158.html

    Release Date: 02-29-2024Open Date: 03-05-2024 Due Dates: Multiple Close Date: 01-06-2027

    Introduction The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH), works to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. Translation is the process of turning observations in the ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. A244-015: Novel Positioning, Navigation, and Timing (PNT) Signal Classification Techniques

    Release Date: 10-03-2023Open Date: 03-04-2024Due Date: 03-31-2025Close Date: 04-22-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted Artificial Intelligence (AI) and Autonomy; Integrated Sensing and Cyber OBJECTIVE: The purpose of this topic is to develop the capability to classify signals in real-time that impact navigation systems. The intent is to better understand the type(s) of signal(s) experienced in relevant environments to appropriately apply mitigation techniques be ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  10. A244-016: Autonomous Optical Sensors

    Release Date: 10-03-2023Open Date: 03-04-2024Due Date: 03-31-2025Close Date: 04-22-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber; Trusted AI and Autonomy; Integrated Network Systems-of-Systems OBJECTIVE: This project aims to develop a portable optical sensor that can capture high-quality real-time imagery data during missile tests. The sensor will be positioned near a missile launcher during the launch or near the target to analyze the terminal phase of t ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
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