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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-21-224: NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)

    Release Date: 05-05-2021Open Date: 08-05-2021 Due Dates: Multiple Close Date: 04-06-2024

    Purpose: To facilitate the cooperation and partnering of public and private funding organizations, universities, academic medical centers, research institutes, contract research organizations, biotechnology companies, and pharmaceutical companies, NINDS has formed the Neurology Network of Excellence in Clinical Trials (NeuroNEXT, www.NeuroNEXT.org). NeuroNEXT has a Clinical Coordinating Center (C ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-21-226: Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed)

    Release Date: 04-30-2021Open Date: 08-05-2021 Due Dates: Multiple Close Date: 09-06-2024

    Many NIH-funded research projects rely on vertebrate and invertebrate animal models to study the basics of biology and physiology, to investigate pathological conditions, to examine disease mechanisms and treatments, and to design novel therapies and translational procedures. In this regard, ORIP plays a vital role through its support of research infrastructures and animal models of human diseases ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-NS-21-022: Translational Neural Devices (U44 Clinical Trial Optional)

    Release Date: 04-28-2021Open Date: 06-01-2021 Due Dates: Multiple Close Date: 02-21-2024

    A. Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical saf ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-DA-22-001: Mobile Health Solutions to rectify digital inequality in communities affected by drug addiction (R43/R44 Clinical Trial Optional)

    Release Date: 04-27-2021Open Date: 07-13-2021Due Date: 08-13-2021Close Date: 08-14-2021

    Background Mobile health technologies, including wearable sensors, mobile apps, social media, and digital therapeutics, have been proposed and used as research tools, service tools, and medical device solutions for patients affected by SUD. The emergency conditions of the SARS-COV-2 pandemic have dramatically expedited adoption and increased the attention to mobile health and remote monitoring an ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-21-233: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 04-23-2021Open Date: 07-10-2021 Due Dates: Multiple Close Date: 04-06-2024

    A. Overview Recent advances in biology offer unprecedented opportunities to discover new treatments for nervous system disorders. Biotherapeutic development, however, has inherent complexities with regards to characterization, manufacturing, delivery, and administration. Many academic laboratories and small business enterprises don’t have the full scope of expertise and resources available; thi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. DLA212-001: Engaging the Manufacturing Industrial Base in Support of DLA’s Critical Supply Chains

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Nuclear; Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Ground Sea; Nuclear; Weapons; Materials; Air Platform The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Expo ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
  7. DLA212-002: Unique Identifier Tags for Supply Chain Tracking Modernization for Mark 39 Expendable Mobile Anti-Submarine Warfare (ASW) Training Target (EMATT)

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Warfighter Requirements (GWR) TECHNOLOGY AREA(S): Ground Sea The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730- ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
  8. DLA212-003: Thermoplastic forming of metallic glasses

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Pa ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
  9. DLA212-004: Rare Earth Metals Production

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Pa ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
  10. DLA212-005: Enhancing the separation technology to recover rare earths (REs) from chemical concentrates or industrial waste feedstock

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Pa ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
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