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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-18-514 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R41/R42 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-06-2018 Due Dates: Multiple Close Date: 01-05-2021

    The Small Business Technology Transfer (STTR) program is a program that expands funding opportunities in the federal innovation research and development (R&D) arena. Central to the program is expansion of the public/private sector partnership to include the joint venture opportunities for small businesses and nonprofit research institutions. The unique feature of the STTR program is the requiremen ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-18-515 : BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)(R41/R42 Clinical Trial Not Allowed)

    Release Date: 12-15-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Background The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is a Presidential project aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and complex ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-18-514 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R41/R42 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Section I. Funding Opportunity Description The Small Business Technology Transfer (STTR) program is a program that expands funding opportunities in the federal innovation research and development (R&D) arena. Central to the program is expansion of the public/private sector partnership to include the joint venture opportunities for small businesses and nonprofit research institutions. The unique ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PAR-18-580: Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (UT2 Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 02-27-2018 Due Dates: Multiple Close Date: 12-04-2020

    Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by supporti ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PA-18-579 : Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R41/R42- Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The overarching goal of the Small Business Technology Transfer Research (STTR) program at the National Institute of Mental Health (NIMH) is to support small businesses in developing technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment o ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-18-617 : NINDS Exploratory Clinical Trials for Small Business (R42 Clinical Trial Required)

    Release Date: 02-01-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose The NINDS is committed to advancing treatments for people burdened by the neurological disorders that fall under the NINDS mission. Traditionally, large pharmaceutical and biotechnology companies, as well as venture capital firms, have provided the resources needed to conduct the clinical studies required to fully develop and commercialize biomedical products and technologies. More rece ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PA-18-609 : Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R41/R42Clinical Trial Not Allowed).

    Release Date: 01-31-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Animal models are essential for research, contributing to the understanding of the pathobiology of human diseases and facilitating the development of diagnostic approaches and therapeutic interventions. A large number of animal genetic stocks, including models of human diseases, have been generated at an unprecedented fast pace due to rapidly evolving gene editing technologies. However, this rapid ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PA-18-709: Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R41/R42 Clinical Trial Not Allowed)

    Release Date: 03-15-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background G-protein coupled receptor proteins (GPCRs) are membrane bound proteins that serve to modulate cellular activities. Many of the GPCRs have potential significance in healthy mental function and in mental disorders, including receptors for most neurotransmitters and neuropeptides. Drugs targeting GPCRs are currently used in the treatment of mental disorders such as schizophrenia, anxie ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PA-18-785 : Wearable Alcohol Biosensors (STTR) (R41/R42- Clinical Trial Optional)

    Release Date: 05-15-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 04-05-2021

    Rapid advances are being made in wearable technology, including clothing, jewelry and other devices with broadly diverse functions that meet medical or consumer needs. This FOA seeks applications from small businesses that propose to design and produce a non-invasive wearable device to monitor blood alcohol levels in real time. Alcohol detection technology for personal alcohol monitoring has b ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-18-802: Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource Settings (R41/R42- Clinical Trial Optional)

    Release Date: 05-24-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose This Funding Opportunity Announcement (FOA) encourages grant applications from SBCs to develop or adapt, apply, and validate existing or emerging technologies into user-friendly, low-resource setting-appropriate technologies for cancer prevention, diagnosis, or treatment. Projects proposed for this FOA will require multidisciplinary efforts to succeed, and, therefore, all app ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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