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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. NIH/NCATS 024: Small Manufacturing Systems to Produce Research Grade Pharmaceutical Intermediates

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    (Fast-Track and Direct to Phase 2 proposals will not be accepted. Phase II information is provided only for informational purposes to assist Phase I offerors with their long-term strategic planning.) Number of anticipated awards: 2 to 3 Budget (total costs, per award): Phase I: $325,000 for 9 months; Phase II: $2,000,000 for 2 years It is strongly suggested that proposals adhere to the above budge ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. NIH/NCI 455: Point-of-Care Detection of Prostate Specific Antigen

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Page 79 Summary Among men, prostate cancer is the second leading caus ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. NIH/NCI 456: Rapid and Affordable Point-of-Care HPV Diagnostics for Cervical Cancer Control

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Only Direct-to-Phase II and Fast-Track proposals will be accepted. Phase I proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATIO ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. NIH/NCI 457: Technologies for Detecting Tumor-Derived Cell Clusters

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary Technologies that can assess metastatic risk early and facili ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. NIH/NCI 458: Microbiome-Based Tests for Cancer Research, Diagnosis, Prognosis and/or Patient Management

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will NOT be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 4-6 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary This proposal is for the development of microbiome-based ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. NIH/NCI 459: Automated Software for Point-of-cCare Testing to Identify Cancer-Associated Malnutrition

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 2-3 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary The NIH Office of Disease Prevention recently held a Pathways ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. NIH/NCI 460: Evaluation Datasets as Medical Device Development Tools for Testing Cancer Technologies

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will NOT be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Page 88 Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary Oncology data science and analytics is a burgeoni ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. NIH/NCI 461: Ultra-Fast Dose Rate (FLASH) Radiation Detectors and Safety Systems for Cancer Treatment

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Number of anticipated awards: 2-3 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary An important development in the field of radiation oncology is de ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. NIH/NCI 462: Organ-on-Chip for Preclinical and Translational Radiobiological Studies

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Number of anticipated awards: 2-3 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Summary 2D monolayer cultures fail to recapitulate the totality of the tu ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. NIH/NCI 463: Translation of Novel Cancer-Specific Imaging Agents and Techniques to Mediate Successful Imageguided Cancer Interventions

    Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023

    Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Number of Anticipated Awards: 3-5 Budget (total cost, per award): Phase I: up to $400,000 for 12 months Phase II: up to $2,000,000 for 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Page 95 Summary The purpose of this technology-agnostic contract solicitation is to br ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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