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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-21-282: Blueprint Medtech: Small Business Translator (U44- Clinical Trial Optional)

    Release Date: 08-20-2021Open Date: 09-20-2021 Due Dates: Multiple Close Date: 06-21-2024

    Blueprint MedTech The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). Innovators developing groundbreaking medical ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. SOCOM244-007 : Thermal Barrier Minimal Deflection Handguard

    Release Date: 10-03-2023Open Date: 05-06-2024Due Date: 03-31-2025Close Date: 06-24-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Future G; Advanced Materials; Human-Machine Interfaces OBJECTIVE: The objective of this topic is twofold. First, research thermodynamics involved in an over the suppressor handguard design. Secondly, designing a handguard with a toolless means of mounting. The Sig Sauer Rattler .300BO weapon system and the Sig Sauer SLH Suppressor is the host weapon asso ...

    SBIRPhase I/Phase IIDepartment of DefenseSpecial Operations Command
  3. SOCOM244-008: Ruggedized Additive Mobile Manufacturing Unit (RAMMU)

    Release Date: 10-03-2023Open Date: 05-06-2024Due Date: 03-31-2025Close Date: 06-24-2024

    OBJECTIVE: The objective of this topic is to develop applied research toward an innovative capability to use additive manufacturing in a deployed environment with the ability to decrease down time for foreign and non-standard weapons parts, motor pool parts, and dental accessories. IMPORTANT: For SOCOM instructions: please visit: https://www.defensesbirsttr.mil/SBIR-STTR/Opportunities/. Go ...

    SBIRPhase I/Phase IIDepartment of DefenseSpecial Operations Command
  4. A244-028: Software Defined RadioHead (SDRH)

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Computing and Software; Integrated Network Systems-of-Systems OBJECTIVE: Develop a radio agnostic Software Defined RadioHead (SDRH) system with the capability to rapidly adapt the radio carrier frequency among diverse targeted frequency bands using analog and/or digital frequency conversion. Frequency translation of the original signal into a br ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  5. A244-029: Multisystem Mobile Corrosion Unit

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials; Advanced Infrastructure & Advanced Manufacturing OBJECTIVE: The objective of this topic is to create a deployable solution for the Army's major corrosion issue, to be able to repair in austere environments while out in the field. DESCRIPTION: The Letterkenny Army Depot (LEAD) has requirements to deploy a mobile corrosion unit ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  6. A244-030: Miniaturization of Hyperspectral Sensors for UAS Applications

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber; Microelectronics OBJECTIVE: Further develop existing sensor or prototype to meet the necessary Size, Weight and Power (SWaP) requirements for integration into various ongoing modernization programs. This topic seeks to develop a direct-to-phase-two, internally calibrated, compact, passive, day/night capable hyperspectral (hu ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  7. A244-031: Advanced Miniature Mission Processor for Hyperspectral Applications

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber; Microelectronics OBJECTIVE: Further develop existing computer or prototype to meet the necessary Size, Weight, and Power (SWaP) requirements for integration into various ongoing modernization programs. This topic seeks to develop a direct-to-phase-two, low-size, weight (

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  8. HR0011SB20244-02: Atmospheric Water Extraction Plus (AWE+)

    Release Date: 10-03-2023Open Date: 05-14-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials OBJECTIVE: AWE+ seeks to develop novel atmospheric water extraction (AWE) technology with potential for energy use below 100Wh electric per liter of water generated across a wide range of environments. Integrate the technology into a proof-of-concept prototype producing potable water with a clear path to full-size implementation. ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Advanced Research Projects Agency
  9. OSD244-P002: Development of novel 5G Open RAN (Radio Access Networks) xApp and rApp Applications Open Topic

    Release Date: 10-03-2023Open Date: 05-15-2024Due Date: 03-31-2025Close Date: 07-08-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): FutureG; Sustainment & Logistics OBJECTIVE: The Department of Defense (DoD) is seeking the development and demonstration of xApps and/or rApps focused on security and security related network measurement. DoD anticipates increasing reliance on 5G and FutureG OpenRAN networks, and needs tools and techniques that will enhance the security and resilience of ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  10. RFA-DA-25-054: Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R43/R44 Clinical Trials Not Allowed)

    Release Date: 01-29-2024Open Date: 06-25-2024Due Date: 07-25-2024Close Date: 07-26-2024

    Background: Drug discovery and development is a high-cost, high-risk, and time-consuming endeavor where the failure rate of therapeutic candidates that enter clinical trials is 90%. Because of this, in recent years, artificial intelligence (AI), including machine learning ( ML) technologies, has been embraced to reduce clinical failure rates and to speed up drug discovery. AI/ML technologies are ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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