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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-19-061 : Computational Genomics and Data Science Opportunities for Small Business (R43/R44 Clinical Trial Not Allowed)

    Release Date: 11-09-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background Since its inception the field of genomics has been grounded in computational approaches. All facets of genomic research, such as processing raw sequencing signals, assembling genomes, calling variants, deriving insight from population sequencing studies, and designing and studying the implementation of genomics in clinical settings, are dependent upon computational, analytical, statist ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. 8.4: Conservation of Natural Resources

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Conservation of Natural Resources topic area aims to develop innovative technologies that are developed with the purpose to conserve, monitor, improve and/or protect the quality and/or quantity of natural resources while sustaining optimal farm and forest productivity and profitability. We encourage new technologies and innovations that will help improve soil health, reduce soil erosion, impro ...

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  3. PA-20-047: Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 01-08-2020Open Date: 03-05-2020 Due Dates: Multiple Close Date: 01-06-2023

    Background Single cell analysis has recently become an active area of research to uncover fundamental biological principles behind cell diversity, which are often masked and not amenable to the population analysis of cells. The past several years have witnessed a rapid advancement in the development of single cell technologies and analysis methods. Multiple single cell "-omics" approaches are eme ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PA-19-076 : Enabling Technologies to Accelerate Development of Oral Biodevices (R43/R44 Clinical Trial Not Allowed)

    Release Date: 11-26-2018Open Date: 03-05-2019 Due Dates: Multiple Close Date: 01-05-2022

    Purpose This Funding Opportunity Announcement (FOA) invites applications that propose transformative engineering solutions to technical challenges associated with new development, substantial optimization of existing technologies and clinical translation of intraoral biodevices. Proposed technologies are expected to advance development of oral biodevices to clinical use, including but not limited ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. 8.5: Food Science and Nutrition

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Food Science and Nutrition topic area aims to fund projects that support research focusing on developing new and improved processes, technologies, or services that address emerging food safety, food processing, and nutrition issues.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  6. 8.1: Forests and Related Resources

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Forests and Related Resources topic area aims to address the health, diversity, and productivity of the Nation’s forests to meet the needs of present and future generations through the development of environmentally sound approaches to increase productivity of forest lands, improve sustainability and develop value-added materials derived from forest resources.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  7. RFA-DA-19-019 : HEAL Initiative: America’s Startups and Small Businesses Build Technologies to Stop the Opioid Crisis (R43/R44- Clinical Trial Optional)

    Release Date: 12-10-2018Open Date: 12-10-2018 Due Dates: Multiple Close Date: 09-08-2021

    The National Center for Advancing Translational Sciences (NCATS) will not accept primary assignment to applications proposing clinical trial(s) under this funding announcement. Please direct any questions to the NCATS scientific contact. Purpose More than 2 million individuals in the United States have an opioid use disorder (OUD), most starting with opioid analgesics prescribed to them or procu ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. RFA-NS-20-010 : HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44- Clinical Trial Required)

    Release Date: 10-04-2019Open Date: 12-08-2019 Due Dates: Multiple Close Date: 09-08-2022

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. RFA-MD-21-006: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 03-11-2021Open Date: 04-05-2021Due Date: 05-03-2021Close Date: 05-04-2021

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PA-18-928 : Innovative Technologies for HIV Behavioral and Social Science Research (R43/R44 Clinical Trial Optional)

    Release Date: 09-19-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background Technology-enabled HIV research has emerged in the past decade as a dynamic field that offers potential to bring HIV prevention and treatment efforts to scale. Technological innovations can help to reach vulnerable and at-risk populations such as minorities, adolescents, older adults, and individuals from rural settings who have challenges accessing conventional prevention and treatmen ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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