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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-24-098: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 01-22-2024Open Date: 02-22-2024 Due Dates: Multiple Close Date: 06-26-2026

    Background A biomarker is a defined characteristic that is measured as an indicator of a normal biological process, pathogenic process, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints. Because the measurement of the biomarker is integral to defining ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-24-066: NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required)

    Release Date: 11-30-2023Open Date: 12-01-2023 Due Dates: Multiple Close Date: 01-08-2027

    This Notice of Funding Opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials related to the research mission of the NEI. This program provides support for milestone-driven, commercialization-oriented clinical trials and will involve participation of NEI program ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-23-311: NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required)

    Release Date: 11-27-2023Open Date: 12-05-2023 Due Dates: Multiple Close Date: 09-06-2026

    NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treatment of n ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-TR-23-017: Miniaturization and Automation of Tissue Chip Systems (MATChS) (U43/U44 Clinical Trial Not Allowed)

    Release Date: 11-22-2023Open Date: 01-22-2024 Due Dates: Multiple Close Date: 02-24-2026

    This Notice of Funding Opportunity (NOFO) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, Phase II, Fast-Track and Direct to Phase II grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose applications to create bench top, portable, autom ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-24-063: Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 11-01-2023Open Date: 01-09-2024 Due Dates: Multiple Close Date: 08-19-2026

    Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food and Drug Admin ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. A244-P017: xTechScalable AI 2

    Release Date: 10-03-2023Open Date: 03-11-2024Due Date: 03-31-2025Close Date: 11-18-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Artificial Intelligence/ Machine Learning; Trusted AI and Autonomy; Advanced Computing and Software; Human-Machine Interfaces OBJECTIVE: Topic 1: Scalable Tools for Automated AI Risk Management and Algorithmic Analysis As the Army deploys Artificial Intelligence (AI) systems, there is an inherent risk that the AI model could fail to perform as expe ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  7. A244-027: xTechSpecial Forces

    Release Date: 10-03-2023Open Date: 04-30-2024Due Date: 03-31-2025Close Date: 10-21-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy; Advanced Computing and Software; Integrated Sensing and Cyber; Microelectronics; Integrated Network Systems-of-Systems; Advanced Materials; Human-Machine Interfaces OBJECTIVE: Topic 1: GPS Denied ATAK Compatible Self Location Application The US Army 1st Special Forces Command (Airborne) is seeking a software solution to obt ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  8. SOCOM244-007 : Thermal Barrier Minimal Deflection Handguard

    Release Date: 10-03-2023Open Date: 05-06-2024Due Date: 03-31-2025Close Date: 06-24-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Future G; Advanced Materials; Human-Machine Interfaces OBJECTIVE: The objective of this topic is twofold. First, research thermodynamics involved in an over the suppressor handguard design. Secondly, designing a handguard with a toolless means of mounting. The Sig Sauer Rattler .300BO weapon system and the Sig Sauer SLH Suppressor is the host weapon asso ...

    SBIRPhase I/Phase IIDepartment of DefenseSpecial Operations Command
  9. SOCOM244-008: Ruggedized Additive Mobile Manufacturing Unit (RAMMU)

    Release Date: 10-03-2023Open Date: 05-06-2024Due Date: 03-31-2025Close Date: 06-24-2024

    OBJECTIVE: The objective of this topic is to develop applied research toward an innovative capability to use additive manufacturing in a deployed environment with the ability to decrease down time for foreign and non-standard weapons parts, motor pool parts, and dental accessories. IMPORTANT: For SOCOM instructions: please visit: https://www.defensesbirsttr.mil/SBIR-STTR/Opportunities/. Go ...

    SBIRPhase I/Phase IIDepartment of DefenseSpecial Operations Command
  10. A244-028: Software Defined RadioHead (SDRH)

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Computing and Software; Integrated Network Systems-of-Systems OBJECTIVE: Develop a radio agnostic Software Defined RadioHead (SDRH) system with the capability to rapidly adapt the radio carrier frequency among diverse targeted frequency bands using analog and/or digital frequency conversion. Frequency translation of the original signal into a br ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
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