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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-18-578: Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (U44- Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 02-27-2018 Due Dates: Multiple Close Date: 12-04-2020

    Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by support ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-18-580: Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (UT2 Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 02-27-2018 Due Dates: Multiple Close Date: 12-04-2020

    Overview This Funding Opportunity Announcement (FOA) encourages the translation of research discoveries into new treatments for disorders that fall under the mission of NIAAA. The goal is to advance the commercialization of small molecules, natural products or biologics that have shown therapeutic potential for alcohol use disorder or alcohol-related diseases in preclinical testing, by supporti ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PA-18-579 : Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R41/R42- Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The overarching goal of the Small Business Technology Transfer Research (STTR) program at the National Institute of Mental Health (NIMH) is to support small businesses in developing technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment o ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PA-18-566 : Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43/R44 Clinical Trial Optional)

    Release Date: 01-12-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Background The overarching goal of the Small Business Innovation Research (SBIR) program at the National Institute of Mental Health (NIMH) is to support small businesses to develop technologies that can advance the mission of the Institute, including basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-18-632 : NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

    Release Date: 02-06-2018Open Date: 04-14-2018 Due Dates: Multiple Close Date: 01-13-2021

    Purpose This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials. A clinical trial is defined by NIH as: "A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-18-628 : NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)

    Release Date: 02-05-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose: To facilitate the cooperation and partnering of public and private funding organizations, universities, academic medical centers, research institutes, contract research organizations, biotechnology companies, and pharmaceutical companies, NINDS has formed the Neurology Network of Excellence in Clinical Trials (NeuroNEXT, www.NeuroNEXT.org). NeuroNEXT has a Clinical Coordinating Center ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PA-18-631 : NIBIB Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required)

    Release Date: 01-05-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to improve health by supporting and conducting interdisciplinary research and training in biomedical imaging and bioengineering, and at the convergence of the physical and biological sciences. This is achieved through supporting the development and early translation of emerging technologies that enable fundam ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-18-617 : NINDS Exploratory Clinical Trials for Small Business (R42 Clinical Trial Required)

    Release Date: 02-01-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose The NINDS is committed to advancing treatments for people burdened by the neurological disorders that fall under the NINDS mission. Traditionally, large pharmaceutical and biotechnology companies, as well as venture capital firms, have provided the resources needed to conduct the clinical studies required to fully develop and commercialize biomedical products and technologies. More rece ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-18-618 : NINDS Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required)

    Release Date: 01-01-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose The NINDS is committed to advancing treatments for people burdened by the neurological disorders that fall under the NINDS mission. Traditionally, large pharmaceutical and biotechnology companies, as well as venture capital firms, have provided the resources needed to conduct the clinical studies required to fully develop and commercialize biomedical products and technologies. More rece ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PA-18-609 : Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R41/R42Clinical Trial Not Allowed).

    Release Date: 01-31-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Animal models are essential for research, contributing to the understanding of the pathobiology of human diseases and facilitating the development of diagnostic approaches and therapeutic interventions. A large number of animal genetic stocks, including models of human diseases, have been generated at an unprecedented fast pace due to rapidly evolving gene editing technologies. However, this rapid ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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