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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. HR0011SB20244-02: Atmospheric Water Extraction Plus (AWE+)

    Release Date: 10-03-2023Open Date: 05-14-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials OBJECTIVE: AWE+ seeks to develop novel atmospheric water extraction (AWE) technology with potential for energy use below 100Wh electric per liter of water generated across a wide range of environments. Integrate the technology into a proof-of-concept prototype producing potable water with a clear path to full-size implementation. ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Advanced Research Projects Agency
  2. A244-053: Automated and Modular Forward Deployed Biomanufacturing Unit for Warfighter Field Feeding at Point of Need

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Biotechnology OBJECTIVE: Advance research that safely produces nutritious foodstuffs via biosynthesis at point of need to overcome contested logistics and sustain the future force with high quality nutrition on-demand that ensures food security DESCRIPTION: Point of need (PON) food production may sustain units deployed in contested logistics (CL) env ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  3. A244-043: Automated Functional Grading of Materials for Directed Energy Deposition Additive Manufacturing

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials OBJECTIVE: Develop software for interfacing closed-network computational processing of CAD models with custom, user-dictated compositional gradients to enable building complex functionally graded materials on a directed energy disposition additive manufacturing system. DESCRIPTION: Current munitions manufacturing is often limited t ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  4. HR0011SB20244-03: Biomaterial Energy Dissipating Structures (BEDS)

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials, Biotechnology OBJECTIVE: Develop novel energy-dissipating biomaterial structures to enable enhanced materiel & equipment airdrop, in support of the DARPA “Waste Upcycling for Defense” (WUD) program. DESCRIPTION: DARPA requests SBIR development on advanced materials to enable critical enhanced airdrop capabilities. Deployable f ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Advanced Research Projects Agency
  5. PAR-21-282: Blueprint Medtech: Small Business Translator (U44- Clinical Trial Optional)

    Release Date: 08-20-2021Open Date: 09-20-2021 Due Dates: Multiple Close Date: 06-21-2024

    Blueprint MedTech The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). Innovators developing groundbreaking medical ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-24-063: Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 11-01-2023Open Date: 01-09-2024 Due Dates: Multiple Close Date: 08-19-2026

    Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food and Drug Admin ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PAR-24-096: Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 01-22-2024Open Date: 02-22-2024 Due Dates: Multiple Close Date: 06-23-2026

    A biomarker is a defined characteristic that is measured as an indicator of a normal biological process, pathogenic process, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints. Because the measurement of the biomarker is integral to defining the biomarke ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. A244-042: Continuous Time Spiking Neural Network Field Programmable Neural Network Array

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Network Systems-of-Systems The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-7 ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  9. RFA-DA-23-021: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44- Clinical Trial Optional)

    Release Date: 03-28-2022Open Date: 07-15-2022 Due Dates: Multiple Close Date: 02-15-2025

    According to the Centers for Disease Control and Prevention (CDC), more than 100,000 deaths from overdose were reported from April 2020 to April 2021 alone. Data shows an increase in overdoses due to natural and semi-synthetic opioids, synthetic opioids, predominantly fentanyl, and psychostimulants, such as methamphetamine or cocaine. In fact, in the year ending in April 2021, fentanyl was the lea ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. RFA-DA-24-038: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R41/R42 Clinical Trial Optional)

    Release Date: 04-19-2023Open Date: 07-15-2023 Due Dates: Multiple Close Date: 02-15-2025

    According to the Centers for Disease Control and Prevention (CDC), more than 100,000 deaths from overdose were reported from April 2020 to April 2021 alone. Data shows an increase in overdoses due to natural and semi-synthetic opioids, synthetic opioids, predominantly fentanyl, and psychostimulants, such as methamphetamine or cocaine. In fact, in the year ending in April 2021, fentanyl was the lea ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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