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Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) grant applications (Phase I [R43] and Phase II [R44]) focused on specific product development activities for radiological/nuclear medical countermeasures leading to Investigational New Drug (IND) or Investigational Device Exemption (IDE) submission packages to the U.S. Foo ...

Despite advances in the treatment of chronic viral hepatitis B and C, the persistence of these and the emergence of other hepatitis viruses continue to remain a public health challenge in the United States. Currently, it is estimated that 3.5 to 5.3 million persons in the United States are afflicted by viral hepatitis. The consequences of acute and chronic viral hepatitis vary, but can be severe a ...

Despite advances in the treatment of chronic viral hepatitis B and C, the persistence of these and the emergence of other hepatitis viruses continue to remain a public health challenge in the United States. Currently, it is estimated that 3.5 to 5.3 million persons in the United States are afflicted by viral hepatitis. The consequences of acute and chronic viral hepatitis vary, but can be severe a ...

The zebrafish is used extensively by NIH funded investigators to examine many aspects of the basic biology of vertebrates and, in the past several years, has become an important model organism for a variety of human diseases. During fiscal year 2013, twenty of the NIH Institutes, Centers and Offices funded approximately 700 grants related to zebrafish research, with an investment totaling approxim ...

The zebrafish is used extensively by NIH funded investigators to examine many aspects of the basic biology of vertebrates and, in the past several years, has become an important model organism for a variety of human diseases. During fiscal year 2013, twenty of the NIH Institutes, Centers and Offices funded approximately 700 grants related to zebrafish research, with an investment totaling approxim ...

Purpose This Funding Opportunity Announcement (FOA) seeks SBIR grant applications from small businesses to develop major advances in genomic technologies.  Advances in genomics and more broadly in biomedical research have been greatly facilitated by significant and sustained genomics technology throughput increases, cost decreases, and improvements in ease of use. The proposed technology deve ...

Purpose This FOA solicits Phase I (R43) or Fast-track (R44) SBIR grant applications from SBCs to develop novel, engineered 3-dimensional or organotypic in vitro systems using cells from experimental animal models typically used for toxicology testing (e.g., rat, mouse, rabbit, or dog) that will replicate biological responses within the corresponding animal tissues or organs and can provide altern ...

Purpose The NINDS is committed to advancing treatments for people burdened by the neurological disorders that fall under the NINDS mission. Traditionally, large pharmaceutical and biotechnology companies, as well as venture capital firms, have provided the resources needed to conduct the clinical studies required to fully develop and commercialize biomedical products and technologies. More recentl ...

Purpose The NINDS is committed to advancing treatments for people burdened by the neurological disorders that fall under the NINDS mission.  Traditionally, large pharmaceutical and biotechnology companies, as well as venture capital firms, have provided the resources needed to conduct the clinical studies required to fully develop and commercialize biomedical products and technologies. More r ...

Purpose The Small Business Innovation Research (SBIR) Program is an important National Institutes of Health (NIH) funding mechanism used to develop innovative solutions that address public health challenges. A major objective of the SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of biomedical technology products ...